Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody-associated demyelination in children

Developmental Medicine and Child Neurology
Sudarshini RamanathanRussell C Dale

Abstract

Myelin oligodendrocyte glycoprotein (MOG) antibodies have a strong association with acute disseminated encephalomyelitis (ADEM) in children, and bilateral and recurrent optic neuritis in children and adults. Recent reports suggest that seizures and encephalopathy may occur in children and adults with MOG antibody-associated disease. We describe the clinical, laboratory, and radiological course of four MOG antibody-positive children who first presented with isolated seizures without fulfilling clinical or radiological criteria for ADEM or other central nervous system demyelination syndromes, who months to years later developed more typical demyelination. This case series highlights a novel observation that isolated seizures in the absence of ADEM may be the index presentation for MOG antibody-associated disease, which should therefore be considered a form of autoimmune epilepsy. It would be reasonable to test for MOG antibodies in children with seizures accompanied by subtle inflammatory changes on magnetic resonance imaging or cerebrospinal fluid analyses, particularly if followed by demyelination, given the clinical and therapeutic implications of an expedited diagnosis in minimizing long-term disability. WHAT THIS PAPER ADDS:...Continue Reading

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Citations

Dec 21, 2018·Developmental Medicine and Child Neurology·Orna O'toole
May 24, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Axel PetzoldGordon T Plant
Sep 5, 2019·Acta Neuropathologica Communications·Fiona TeaUNKNOWN Australasian and New Zealand MOG Study Group
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Mar 3, 2020·Frontiers in Immunology·Fiona TeaUNKNOWN Australasian New Zealand MOG Study Group
Jul 10, 2019·Epilepsia·Alberto VogrigJérome Honnorat
Oct 9, 2020·Therapeutic Advances in Neurological Disorders·Harald Hegen, Markus Reindl
Nov 8, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Matthias BaumannUNKNOWN E.U. paediatric MOG consortium
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Aug 22, 2021·Lancet Neurology·Romain MarignierBernhard Hemmer
Mar 31, 2020·Multiple Sclerosis and Related Disorders·Chun-Hong ShenMei-Ping Ding

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