Isolated tumor cells in esophageal cancer: implications for the surgeon and the pathologist

Annals of Surgery
Sarah K ThompsonPeter G Devitt

Abstract

Studies suggest that up to 56% of node-negative patients have tumor deposits in their lymph nodes that are missed by routine pathologic examination. However, few studies differentiate between isolated tumor cells and micrometastases using reproducible criteria, and their prognostic significance has not been established. We identified 119 patients who had undergone surgical resection for esophageal cancer between 1997 and 2007, and who were classified as node-negative. Relevant paraffin blocks were identified, and 3 additional levels, each 250 mum apart, were cut of all lymph nodes. Isolated tumor cells and micrometastases were defined according to size criteria but additional data and characteristics were recorded. Two slides were made at each level (1 for hematoxylin and eosin, 1 for immunohistochemistry). Results were correlated with survival. One patient was found to have a metastasis (>2 mm), 8 patients (7%) had micrometastases, and 22 patients (18%) had isolated tumor cells. The 5-year survival rates were 60% for patients who remained node-negative, 33% for patients with isolated tumor cells, 40% for patients with micrometastases, and 0 for the patient with a metastasis (P = 0.02). A significant difference was found betwee...Continue Reading

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Citations

Aug 3, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sarah K ThompsonGlyn G Jamieson
Jul 26, 2011·Annals of Surgery·Raffaello Incarbone
May 16, 2014·Annals of Surgical Innovation and Research·George L Balalis, Sarah K Thompson
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Nov 11, 2017·Future Oncology·Emma UpchurchHugh Barr
Jan 29, 2014·International Journal of Cancer. Journal International Du Cancer·Marnie WinterBenjamin Thierry
Aug 21, 2013·American Journal of Surgery·Da WangJohn T Plukker
Dec 4, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lien Van De VoordePhilippe Lambin

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