Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival

BMC Cancer
B WeixlerM Zuber

Abstract

Lymph node (LN) involvement represents the strongest prognostic factor in colon cancer patients. The objective of this prospective study was to assess the prognostic impact of isolated tumor cells (ITC, defined as cell deposits ≤ 0.2 mm) in loco-regional LN of stage I & II colon cancer patients. Seventy-four stage I & II colon cancer patients were prospectively enrolled in the present study. LN at high risk of harboring ITC were identified via an in vivo sentinel lymph node procedure and analyzed with multilevel sectioning, conventional H&E and immunohistochemical CK-19 staining. The impact of ITC on survival was assessed using Cox regression analyses. Median follow-up was 4.6 years. ITC were detected in locoregional lymph nodes of 23 patients (31.1%). The presence of ITC was associated with a significantly worse disease-free survival (hazard ratio = 4.73, p = 0.005). Similarly, ITC were associated with significantly worse overall survival (hazard ratio = 3.50, p = 0.043). This study provides compelling evidence that ITC in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival. Based on these data, the presence of ITC should be classified as a high risk factor in stage I & ...Continue Reading

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Citations

May 10, 2017·The International Journal of Biological Markers·Changzheng DuJin Gu
May 23, 2019·Applied Health Economics and Health Policy·Sherley Diaz-MercedesMiriam Cuatrecasas
Feb 25, 2019·European Journal of Nuclear Medicine and Molecular Imaging·M AnkersmitW J H J Meijerink
Sep 8, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Likui Qiao
Nov 3, 2017·World Journal of Gastroenterology : WJG·Chong-Bing SunFu-Chang Zheng

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

R package “ relsurv ”
R

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