Abstract
Muntingia calabura L. has been used in Southeast Asia and tropical America as antipyretic, antiseptic, analgesic, antispasmodic and liver tonic. This study aims to determine the acute toxicity and the metabolic pathways involved in the hepatoprotective mechanism of M. calabura. CCl4-induced hepatotoxic rat model was developed and a dose dependent effect of M. calabura was conducted. Body weight, food and water consumption were measured every day and rats were sacrificed to collect the serum samples at the end of the 10-days treatment. Liquid chromatography-mass spectrometry quadrapole time of flight (LC/MS-QTOF) combined with principal component analysis (PCA) were used to determine differentially expressed metabolites due to treatment with CCl4 and M. calabura extracts. Metabolomics Pathway Analysis (MetPA) was used for analysis and visualization of pathways involved. Body weight, food and water consumption were significantly decreased and histopathological study revealed steatosis in CCl4-induced rats. PCA score plots show distinct separation in the metabolite profiles of the normal group, CCl4-treated group and extract of M. calabura (MCME) pre-treated groups. Biomarkers network reconstruction using MetPA had identified 2 ma...Continue Reading
References
Feb 1, 1991·The Journal of Clinical Investigation·C A BrassJ L Gollan
Mar 25, 2000·Chemico-biological Interactions·R C ZangarD L Springer
Feb 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E Porchezhian, S H Ansari
Oct 29, 2005·Planta medica·Jih-Jung ChenIh-Sheng Chen
Apr 30, 2008·World Journal of Gastroenterology : WJG·Mohammed IbrahimChitoor Mohammed Habibullah
May 10, 2008·European Journal of Gastroenterology & Hepatology·Márcia M AranhaCecília M P Rodrigues
Jan 8, 2011·The American Journal of Chinese Medicine·Z A ZakariaM Z Salleh
Jan 29, 2011·Congestive Heart Failure·Ning LiNipavan Chiamvimonvat
May 14, 2011·The Journal of Biological Chemistry·Guo-Fang ZhangHenri Brunengraber
Oct 13, 2011·Journal of Lipids·Tiangang Li, John Y L Chiang
Aug 1, 2012·International Journal of Vascular Medicine·Scott J ThomsonDavid Bishop-Bailey
May 28, 2013·Journal of Ethnopharmacology·Gao ZhouYouwei Wang
Citations
Feb 13, 2016·Frontiers in Pharmacology·Xiao MaXiao-He Xiao
Sep 14, 2016·Journal of Ethnopharmacology·Cong-En ZhangXiao-He Xiao
Apr 5, 2017·Food & Function·Jau-Tien LinDeng-Jye Yang
Dec 3, 2015·Scientific Reports·He ZhuSong-Lin Li
Feb 22, 2017·Journal of Pharmaceutical and Biomedical Analysis·Jie XingZhen-Yu Li
Feb 25, 2017·Food & Function·Jau-Tien LinDeng-Jye Yang
Sep 23, 2018·Biomedical Chromatography : BMC·Thidarat IntararuchikulRossarin Tansawat
Sep 6, 2017·Pharmaceutical Biology·Nur Liana Md NasirZainul Amiruddin Zakaria
Dec 27, 2016·Frontiers in Pharmacology·Chun-Yu LiJia-Bo Wang
Mar 6, 2019·World Journal of Gastroenterology : WJG·Jiong YuLan-Juan Li
Jul 1, 2018·Natural Products and Bioprospecting·Qi ZhaoFei Li
Oct 17, 2019·Metabolites·Renhao ChenHui Zhang
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Xiao MengHua-Bin Li
Jul 18, 2020·Journal of Ethnopharmacology·Zhao-Jie WangXiao-Dong Luo
Aug 23, 2018·Chemical Research in Toxicology·Yue ZhangKun Zhou