Isolation and absolute configurations of diastereomers of 8α-hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol from Chimonanthus salicifolius

Phytochemistry
Dan LiKui-Wu Wang

Abstract

Phytochemical investigation of the aerial parts of Chimonanthus salicifolius resulted in the isolation of two sesquiterpenoids, 8α-hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol, together with 13 known compounds. The 15 structures were established by means of 1D and 2D NMR spectroscopy. The relative and absolute configurations of 8α-hydroxy-T-muurolol and 8α,11-elemodiol were achieved by NOESY experiments and X-ray crystallography using CuKα radiation. 8α-hydroxy-T-muurolol and (1α,6β,7β)-cadinane-4-en-8α,10α-diol showed immunosuppressive activities in a dose-dependent manner.

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Citations

Apr 24, 2017·Chemistry & Biodiversity·Xiao-Wei ZhangMan-Qing Zhou
Aug 3, 2018·Topics in Current Chemistry·A Sajeli Begum, S Santhosh Kumar
Jun 12, 2020·The Plant Journal : for Cell and Molecular Biology·Qundan LvKejun Cheng
May 29, 2019·Natural Product Research·Kui-Wu WangHong Wang

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