PMID: 9537580Apr 16, 1998Paper

Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma

International Journal of Cancer. Journal International Du Cancer
A M MehlF A Grässer

Abstract

Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gene, leading to amino-acid exchanges. The LMP1 gene from passenger lymphocytes showed identical point mutations, but also had an in-frame insertion of 132 base pairs within the 33-bp repeat region. This insert encoding 44 amino acids contained the sequence PSQQS, corresponding to the potential TRAF-binding motif PXQXT/S. When compared to the B95.8 gene, both HD-derived LMP1 genes showed an increase in the transformation of Rat-1 rodent fibroblasts. The transforming ability of the LMP1 gene with the insertion was greater than that of the other HD-derived LMP1, and was comparable with the highly transforming LMP1-Cao gene derived from a nasopharyngeal carcinoma. The HD-derived genes stimulated expression of the cell-surface markers, CD40 and CD54, similarly to the LMP1-B95.8 gene, while the LMP1-Cao gene had a significantly reduced ability to induce these proteins. In contrast, the LMP1-Cao transactivated an NF-kappaB-response element mo...Continue Reading

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H HerbstH Stein
May 1, 1988·The Journal of General Virology·L S YoungA B Rickinson
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Citations

Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·Lian-hua KimSibrand Poppema
Apr 17, 2004·British Journal of Haematology·Maher K GandhiRajiv Khanna
Oct 21, 2011·Journal of Medical Virology·Beata KasztelewiczKatarzyna Dzierżanowska-Fangrat
Oct 24, 2001·Seminars in Cancer Biology·S Pai, R Khanna
Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·P HahnF A Grässer
Jan 23, 1999·Current Opinion in Hematology·D E Mosier
Apr 11, 2006·The Journal of General Virology·Melanie M Brinkmann, Thomas F Schulz
May 30, 2001·Trends in Molecular Medicine·R KhannaL Cooper

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