Isolation and biological effects of 7-O-methyleriodictyol, a flavanone isolated from Artemisia monosperma, on rat isolated smooth muscles

Planta medica
L Abu-NiaajS Abdalla

Abstract

The isolation for the first time from the genus Artemisia (Compositae) of the known flavanone, 7-O-methyleriodictyol (7-methoxy-5,3',4'-trihydroxy-flavanone), its identification, and its biological effects on rat isolated smooth muscles are described. 7-O-Methyleriodictyol (10(-7) M to 3 x 10(-4) M) caused concentration-dependent inhibition of the amplitude of the phasic contractions and reduced the tone of the ileum, the uterus, and the urinary bladder. It also caused relaxation of the phenylephrine-precontracted pulmonary artery and the acetylcholine-precontracted trachea. The flavanone also shifted to the right the acetylcholine concentration-effect curve on the ileum and the oxytocin concentration-effect curve on the uterus. The maximum contractions induced by acetylcholine or oxytocin were also inhibited by 7-O-methyleriodictyol. These antispasmodic effects are partly consistent with the use of A. monosperma in folk medicine for certain gastrointestinal disorders.

Citations

May 23, 1998·Annual Review of Pharmacology and Toxicology·M HeinrichE Rodriguez
Jan 20, 2010·Journal of Ethnopharmacology·Abdalla Mohammad Hijazi, Abdullazim Sammour Salhab
Nov 5, 2013·Journal of Ethnopharmacology·T A F EissaM P Gómez-Serranillos
Nov 8, 2018·BioMed Research International·Edith Fabiola Martínez-PérezHoracio Bach

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