Isolation and characterisation of a surface membrane glycoprotein from adult Schistosoma mansoni

Molecular and Biochemical Parasitology
A N MacGregor, J R Kusel

Abstract

A peanut agglutinin-binding glycoprotein in adult Schistosoma mansoni was shown to be absent from pre-liver worms, but could be detected on the worm surface in large amounts at four weeks post-infection. Four-week parasites incubated with fluorescein isothiocyanate-peanut agglutinin showed a general surface fluorescence. The molecule did not incorporate methionine or palmitate. ELISA using the isolated glycoprotein showed the presence of antibodies to it in serum from infected mice and from humans infected with S. mansoni and Schistosoma haematobium. The implications of these results for surface membrane development are discussed.

References

Jan 1, 1978·Advances in Carbohydrate Chemistry and Biochemistry·I J Goldstein, C E Hayes
Dec 20, 1979·Biochimica Et Biophysica Acta·R Lotan, G L Nicolson
Dec 1, 1978·Experimental Parasitology·K D MurrellD A Dean
Apr 1, 1986·Experimental Parasitology·W Harnett, J R Kusel
Aug 1, 1985·Molecular and Biochemical Parasitology·A N MacGregorJ R Kusel
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N P Robertson, G D Cain
Aug 1, 1974·International Journal for Parasitology·L H Chappell
Feb 1, 1974·Experimental Parasitology·D G Colley, S K Wikel
Mar 1, 1983·Molecular and Biochemical Parasitology·F D Rumjanek, M Curiel
Apr 1, 1965·Experimental Parasitology·J A CLEGG

Citations

Feb 1, 1996·Parasitology Today·R L Jacobson, R J Doyle
Mar 13, 1998·Molecular and Biochemical Parasitology·C A RedmanJ R Kusel

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.