PMID: 9531986Apr 9, 1998Paper

Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition

The Journal of Antibiotics
O S KinsmanM V Hayes

Abstract

A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.

Citations

Sep 17, 1998·The Journal of Biological Chemistry·M G Gómez-Lorenzo, J F García-Bustos
Mar 30, 2012·Natural Product Research·Shigeru KitaniTakuya Nihira
May 27, 2004·Natural Product Reports·Hideaki Oikawa, Tetsuo Tokiwano
Oct 22, 2002·Expert Opinion on Therapeutic Targets·Joy Sturtevant
May 21, 2010·Natural Product Reports·Roberto Di Santo
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·L CapaJ F García-Bustos
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·J M Domínguez, J J Martín
Mar 6, 1999·Current Opinion in Microbiology·N H Georgopapadakou
Apr 15, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M F VicenteF Peláez
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·J M DomínguezJ J Martín
Mar 3, 2009·Mycological Research·Francisca VicenteFernando Peláez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.