PMID: 7237482Mar 2, 1981

Isolation and characterisation of glycopeptides from digests of human Tamm-Horsfall glycoprotein

Carbohydrate Research
A M Afonso

Abstract

Glycopeptides were isolated from pronase digests of human Tamm-Horsfall glycoprotein and its asialo derivative. The carbohydrate moiety of the major glycopeptide preparation isolated from the former digests had an apparent molecular weight of 4300, and those of two glycopeptides isolated from the latter digests had molecular weights of 3600 and 2300. These data, together with the compositions of the glycopeptides, indicate that the Tamm-Horsfall glycoprotein has at least five asparagine residues substituted by complex carbohydrate moieties, three being of one type, relatively rich in galactose, and two containing more sialic acid but less galactose. A small amount of a mannose-rich glycopeptide was also recovered from the digests of the Tamm-Horsfall glycoprotein.

References

Jan 1, 1976·Kidney International·F Allen, C C Tisher
Apr 18, 1979·Biochimica Et Biophysica Acta·W van DijkW Ferwerda
Sep 15, 1977·The Biochemical Journal·F Serafini-Cessi
Jan 1, 1976·Annual Review of Biochemistry·C J Waechter, W J Lennarz
Nov 28, 1972·Biochimica Et Biophysica Acta·A J CleaveA R Peacocke
Sep 1, 1972·The American Journal of Cardiology·R KlintM Bloom
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C C van der Rijt, L van Zuijlen
Mar 1, 1957·Archives of Biochemistry and Biophysics·H ROSEN
May 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·I TAMM, F L HORSFALL

Citations

Jan 13, 1999·Glycobiology·J J van RooijenJ F Vliegenthart
Oct 1, 1992·Zentralblatt für Veterinärmedizin. Reihe A·D C RhodesE C Hawkins
Feb 1, 1990·Kidney International·J K HortonJ D Williams
Jan 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tsai-Hung WuChang-Youh Tsai
Mar 5, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Syue-Cian SiaoChia-Li Yu

Related Concepts

UMOD protein, human
Asialoglycoproteins
Glycopeptides
Neoglycoproteins
Mucoproteins
Pronase
Tamm-Horsfall protein

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