Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.

Xing-Yi GeZheng-Li Shi


The 2002-3 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV) was one of the most significant public health events in recent history. An ongoing outbreak of Middle East respiratory syndrome coronavirus suggests that this group of viruses remains a key threat and that their distribution is wider than previously recognized. Although bats have been suggested to be the natural reservoirs of both viruses, attempts to isolate the progenitor virus of SARS-CoV from bats have been unsuccessful. Diverse SARS-like coronaviruses (SL-CoVs) have now been reported from bats in China, Europe and Africa, but none is considered a direct progenitor of SARS-CoV because of their phylogenetic disparity from this virus and the inability of their spike proteins to use the SARS-CoV cellular receptor molecule, the human angiotensin converting enzyme II (ACE2). Here we report whole-genome sequences of two novel bat coronaviruses from Chinese horseshoe bats (family: Rhinolophidae) in Yunnan, China: RsSHC014 and Rs3367. These viruses are far more closely related to SARS-CoV than any previously identified bat coronaviruses, particularly in the receptor binding domain of the spike protein. Most importantly, we report the first record...Continue Reading


Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Dec 13, 2003·The Journal of Biological Chemistry·Swee Kee WongMichael Farzan
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Huai-Dong SongGuo-Ping Zhao
Mar 26, 2005·The EMBO Journal·Wenhui LiMichael Farzan
Sep 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanna K P LauKwok-Yung Yuen
Oct 1, 2005·Science·Wendong LiLin-Fa Wang
Feb 9, 2008·Emerging Infectious Diseases·Jie CuiShuyi Zhang
Nov 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michelle M BeckerMark R Denison
Feb 26, 2009·Emerging Infectious Diseases·Suxiang TongCharles E Rupprecht
Jan 22, 2010·Journal of Virology·Yan LiZhengli Shi
Aug 28, 2010·Bioinformatics·Darren P MartinPierre Lefeuvre
Feb 1, 2012·The Journal of Biological Chemistry·Kailang WuFang Li
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Dec 4, 2012·Lancet·Stephen S MorsePeter Daszak
Feb 1, 2013·The Journal of General Virology·S J AnthonyW I Lipkin
Sep 21, 2013·Emerging Infectious Diseases·Ndapewa Laudika ItheteWolfgang Preiser
Nov 12, 2013·Emerging Infectious Diseases·Ziad A MemishW Ian Lipkin

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Datasets Mentioned


Methods Mentioned

electron microscopy

Software Mentioned

Clustal X
Recombination Detection Program ( RDP )

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