Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.

Nature
Xing-Yi GeZheng-Li Shi

Abstract

The 2002-3 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV) was one of the most significant public health events in recent history. An ongoing outbreak of Middle East respiratory syndrome coronavirus suggests that this group of viruses remains a key threat and that their distribution is wider than previously recognized. Although bats have been suggested to be the natural reservoirs of both viruses, attempts to isolate the progenitor virus of SARS-CoV from bats have been unsuccessful. Diverse SARS-like coronaviruses (SL-CoVs) have now been reported from bats in China, Europe and Africa, but none is considered a direct progenitor of SARS-CoV because of their phylogenetic disparity from this virus and the inability of their spike proteins to use the SARS-CoV cellular receptor molecule, the human angiotensin converting enzyme II (ACE2). Here we report whole-genome sequences of two novel bat coronaviruses from Chinese horseshoe bats (family: Rhinolophidae) in Yunnan, China: RsSHC014 and Rs3367. These viruses are far more closely related to SARS-CoV than any previously identified bat coronaviruses, particularly in the receptor binding domain of the spike protein. Most importantly, we report the first record...Continue Reading

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Citations

Mar 25, 2014·Emerging Infectious Diseases·Patrick C Y WooKwok-Yung Yuen
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Datasets Mentioned

BETA
RsSHC014
KC881006

Methods Mentioned

BETA
PCR
electron microscopy
FCS
PCRs

Software Mentioned

Simplot
DNAStar
Clustal X
bootscan
ClustalX
Geneious
BioEdit
Recombination Detection Program ( RDP )
GeneDoc
ClustalW

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