Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase

Biochemical and Biophysical Research Communications
H IchinoseToshiharu Nagatsu

Abstract

The nucleotide sequence of a cDNA clone that includes the entire coding region of human aromatic L-amino acid decarboxylase gene is presented. A human pheochromocytoma cDNA library was screened using an oligonucleotide probe which corresponded to a partial amino acid sequence of the enzyme purified from the human pheochromocytoma. The isolated cDNA clone encoded a protein of 480 amino acids with a calculated molecular mass of 53.9 kDa. The amino acid sequence Asn-Phe-Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes.

Citations

Sep 23, 1997·Protein Science : a Publication of the Protein Society·P DominiciC B Voltattorni
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C VassortC Szpirer
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H IchinoseToshiharu Nagatsu
Jul 30, 2005·Histochemistry and Cell Biology·Michail S DavidoffDieter Müller
Jun 11, 2010·Molecular Biology Reports·Ioanna ChalatsaDido Vassilacopoulou
May 17, 1995·Biochimica Et Biophysica Acta·P J KaisakiP J Kaisakia
Feb 1, 1992·Biochimica Et Biophysica Acta·S NasrinToshiharu Nagatsu
Oct 1, 1991·Neuroscience Research·Toshiharu Nagatsu
Mar 1, 1993·Brain Research. Molecular Brain Research·A Le Van ThaiM J Weber
Sep 1, 1992·Neurochemistry International·K P GudehithluM Hadjiconstantinou
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·Toshiharu Nagatsu, H Ichinose
Jun 9, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Vachtenheim, H Novotná
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M KriegerJ Thibault
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·V R AlbertA Aguanno
Jan 1, 1994·Journal of Ocular Pharmacology·N H Neff, M Hadjiconstantinou
Dec 29, 1995·Annals of the New York Academy of Sciences·Toshiharu NagatsuH Ichinose
Jul 13, 2002·American Journal of Medical Genetics·Esther JahnesMarcella Rietschel
May 12, 2010·Journal of Neurochemistry·A M DucheminM Hadjiconstantinou
Aug 1, 1997·Biochemical Pharmacology·J R BarrioM E Phelps
Apr 30, 2008·Human Mutation·Jan HaavikBeat Thöny
Apr 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanping LiQiong Shi
Jan 1, 2007·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Toshiharu Nagatsu
Jan 1, 1996·Journal of Cellular Biochemistry. Supplement·M D VosA M Treston

Related Concepts

Adrenal Cancer
Metazoa
Aromatic-L-Amino-Acid Decarboxylases
DNA Sequence
DNA, Neoplasm
Drosophila
Cistron
Genomic Hybridization
Pheochromocytoma, Extra-Adrenal
Homologous Sequences, Nucleic Acid

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