PMID: 3768888Aug 15, 1986Paper

Isolation and characterization of a receptor lectin specific for galactose/N-acetylgalactosamine from macrophages

Carbohydrate Research
T KawasakiI Yamashina

Abstract

Rat-peritoneal macrophages are shown to be able to take up glycoproteins terminated by galactose as well as those by mannose and/or N-acetylglucosamine. A lectin responsible for the uptake of galactose-terminated glycoproteins was isolated by affinity chromatography on a column of Sepharose 4B-asialoorosomucoid. The macrophage lectin isolated shared many properties in common with the well-established hepatic lectin specific for galactose/N-acetylgalactosamine. Thus, the lectin bound to asialoglycoproteins specifically, and the binding was inhibited by galactose and N-acetylgalactosamine. The lectin had a single major component of mol. wt. 42,000 as well as two minor components of 60,000 and 65,000, and required calcium for binding. In addition, the macrophage lectin was immunologically crossreactive with the hepatic lectin. Despite these similarities, however, the macrophage lectin was differentiated from the hepatic lectin in molecular size, relative preponderance of minor components, and titration profile with the antibodies raised against the hepatic galactose/N-acetylgalactosamine-specific lectin.

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Citations

Feb 13, 2001·Biochemical and Biophysical Research Communications·R KatsuyamaT Kawasaki
Feb 1, 1997·European Journal of Biochemistry·H MorioT Kawasaki
Feb 1, 1997·European Journal of Biochemistry·H J Gabius
Jan 12, 2011·Annual Review of Immunology·Santiago F GonzalezMichael C Carroll
Feb 6, 2008·Trends in Immunology·Sandra J van VlietYvette van Kooyk
Apr 25, 2012·Annals of the New York Academy of Sciences·Gabriel A RabinovichBrian A Cobb
Oct 29, 2014·Journal of Applied Toxicology : JAT·Jong Kwon LeeWan-Seob Cho
Aug 1, 2012·Biochimica Et Biophysica Acta·Anne Louise Tølbøll SørensenHans H Wandall
Sep 10, 2014·Frontiers in Immunology·Ling Yen LeeMorten Thaysen-Andersen
Jul 19, 2005·Biomaterials·Fatiha ChellatL'Hocine Yahia
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Noriaki KitamuraKiyoshi Furukawa
Nov 30, 2011·Journal of Leukocyte Biology·Sarah L LondriganPatrick C Reading
Feb 26, 2000·European Journal of Biochemistry·A MedeirosE Osinaga
Jul 25, 1998·The Journal of Biological Chemistry·A R KolatkarW I Weis
Jun 10, 2017·International Journal of Molecular Sciences·Guillaume PoirouxPierre Rougé

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