PMID: 9161709May 1, 1997Paper

Isolation and characterization of AFP-binding proteins from tumor and fetal human tissues

Biochemistry and Molecular Biology International
Kanevsky VYuE S Severin

Abstract

The AFP receptor (rAFP) was discovered in embryonal and tumor tissues with a high level of proliferation. The AFP-binding protein (AFPbp) possibly containing the AFP-receptor (rAFP) was isolated from human embryos and human breast cancer tissue using affinity chromatography on an AFP-Sepharose column. The similarity of molecular weight, subunit composition, and immunological characteristics was shown for embryonal and tumor AFPbp using immunoblotting, gel-filtration, and PAAG electrophoresis. Judging from Superose-12 gel-filtration data, the protein molecular weight made up to 320-380 kDa. The presence of an IgG-binding site was detected in embryonal and tumor AFPbp by Western blot analysis.

Citations

Dec 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gerald J Mizejewski
Jun 1, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Janneta TcherkassovaRicardo Moro
Mar 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G J Mizejewski
Jul 18, 2002·Annals of the New York Academy of Sciences·P G SveshnikovE S Severin
Dec 8, 2011·World Journal of Gastroenterology : WJG·Peng LiHui-Guo Ding
Jun 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G J Mizejewski
May 2, 2009·The Journal of Bone and Joint Surgery. British Volume·D AllenS Doucette
Jun 5, 2002·World Journal of Gastroenterology : WJG·Meng-Sen LiGang Li

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