Isolation and characterization of all-trans-retinoic acid-responsive genes in the rat testis

Molecular Reproduction and Development
I C GaemersD G De Rooij

Abstract

By way of differential screening of testis cDNA libraries from vitamin A-deficient (VAD) rats before and after administration of all-trans retinoic acid (ATRA), genes, the transcription of which was influenced by ATRA, were isolated. Most clones with an increased transcription encoded different subunits of the same mitochondrial protein complex, cytochrome c oxidase (COX). The mRNA expression of COX increased by a factor 3.9 +/- 1.5 (mean +/- SD, n = 4). This increased expression seems to reflect an increased energy demand in the ATRA-supplemented VAD testis. Also, one gene was isolated, the transcription of which was reduced to about 70% by ATRA. This gene, sulfated glycoprotein 2 (Sgp-2), is a major secretion product of Sertoli cells, the function of which is still unknown. The effect of ATRA on Sgp-2 expression may be direct, since the promoter of Sgp-2 contains a putative ATRA-responsive element (RARE).

References

Nov 1, 1979·Biology of Reproduction·H F Huang, W C Hembree
Nov 1, 1991·DNA and Cell Biology·C K GlassZ H Han
Aug 1, 1990·Archives of Biochemistry and Biophysics·R A Capaldi
Dec 17, 1987·Nature·V GiguereR M Evans
Feb 29, 1988·Biochemical and Biophysical Research Communications·R ul Haq, F Chytil
Jun 1, 1987·Developmental Biology·S Hugly, M Griswold
May 1, 1987·Biology of Reproduction·C MoralesM D Griswold
Jul 1, 1987·Endocrinology·C Morales, M D Griswold
Dec 1, 1986·Archives of Biochemistry and Biophysics·M A KesslerH F DeLuca
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Dec 14, 1984·Biochemical and Biophysical Research Communications·E UnniM R Rao
Apr 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L WalterE Günther
Feb 1, 1994·Developmental Biology·L J JonkW Kruijer
Feb 18, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J N THOMPSONG A PITT

❮ Previous
Next ❯

Citations

Apr 11, 2001·Mutation Research·C D Berdanier, H B Everts
Dec 6, 2001·Diabetes Research and Clinical Practice·C D BerdanierC E Mathews
Apr 30, 1999·Molecular and Cellular Endocrinology·H K LeeJ Soh
Dec 14, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Augusto OrlandiLuigi Giusto Spagnoli
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S R FlorellS A Leachman
Mar 13, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·François CasasChantal Wrutniak-Cabello
Oct 25, 2006·Experimental Biology and Medicine·Carolyn D Berdanier
Nov 1, 2007·Journal of Cell Science·Joao M Facucho-OliveiraJustin C St John
Aug 23, 2021·The Journal of Biological Chemistry·Yaxin ZhaoJoseph L Napoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.