PMID: 9418061Jan 7, 1998Paper

Isolation and characterization of an antibiotic produced by the scab disease-suppressive Streptomyces diastatochromogenes strain PonSSII

Journal of Industrial Microbiology & Biotechnology
E C Eckwall, J L Schottel

Abstract

An antibiotic produced by the scab disease-suppressive Streptomyces diastatochromogenes strain PonSSII has been isolated and partially characterized. The antibiotic is produced throughout culture growth, with maximum amounts accumulating in the broth when the culture is in the early stationary phase of growth. The activity declines within about 30 h after the culture enters stationary phase. Purification techniques included chromatography on Amberlite XAD-2, DEAE Sephadex and SP Sephadex in addition to C18 HPLC with an average yield of 75%. This antibiotic only inhibits pathogenic strains of S. scabies that cause scab disease on potato and other tuberous vegetables and does not affect S. griseus, S. venezuelae, Actinomyces bovis, Nocardia asteroides, Clostridium perfringens, Bacillus subtilis, Staphylococcus aureus, S. epidermidis, Enterococcus faecalis, Micrococcus luteus, Serratia marcescens and Escherichia coli. The antibiotic has a molecular weight of 500 or less, and is stable for weeks at acidic pH but is very labile at alkaline pH conditions.

Citations

Jul 31, 2002·Annual Review of Phytopathology·David M WellerLinda S Thomashow
Jun 18, 2005·Journal of Applied Microbiology·J S HanJ W Suh
Mar 9, 2018·The Journal of Antibiotics·Marilize Le Roes-HillPaul R Meyers
Feb 26, 2019·Frontiers in Microbiology·Arslan SarwarAndreas Bechthold
May 19, 2001·Canadian Journal of Microbiology·E C Neeno-EckwallJ L Schottel

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