PMID: 9643477Jun 27, 1998Paper

Isolation and characterization of an endogenous inhibitor of phospholipase A2 from Indian cobra (Naja naja naja) venom

Toxicon : Official Journal of the International Society on Toxinology
L M Rudrammaji, T V Gowda

Abstract

A PLA2-inhibitor has been purified from Indian cobra (Naja naja naja) venom by the combination of ion-exchange and gel-filtration chromatography. The inhibitor, NN-I3 was a peptide with mol.wt 6500 and has a fluorescence emission maxima ca 340 nm. NN-I3 specifically inhibited the enzyme activity of the three acidic PLA2 from the same venom. The inhibition of NN-I2d-PLA2 and NN-I2c-PLA2 by NN-I3 was of mixed type and NN-I2c-PLA2 was of uncompetitive type. Neither the inhibitor nor the individual mixtures of acidic PLA2 with the inhibitor (1:1 w/w or 1:2 mol:mol) were lethal to mice when injected intraperitoneally in doses up to 10 mg kg(-1) body weight.

References

Aug 1, 1978·Archives of Biochemistry and Biophysics·R L Cate, A L Bieber
Oct 22, 1975·Biochimica Et Biophysica Acta·H BreithauptJ Lang
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·S Kasturi, T V Gowda
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·M K Bhat, T V Gowda
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J Meier, R D Theakston
Nov 1, 1971·Archives of Biochemistry and Biophysics·J C Vidal, A O Stoppani
Apr 1, 1970·European Journal of Biochemistry·B M BragancaR Y Sambray
Jul 15, 1998·Toxicon : Official Journal of the International Society on Toxinology·L M Rudrammaji, T V Gowda
Jan 1, 1965·Journal of the American Oil Chemists' Society·W S SINGLETONJ L WHITE

❮ Previous
Next ❯

Citations

Oct 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·B S Basavarajappa, T V Gowda
Sep 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·B S BasavarajappaT V Gowda
Oct 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·B N PrasadT V Gowda
Mar 27, 2003·Toxicon : Official Journal of the International Society on Toxinology·I Birgitta SundellR David G Theakston
Jul 15, 1998·Toxicon : Official Journal of the International Society on Toxinology·L M Rudrammaji, T V Gowda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicon : Official Journal of the International Society on Toxinology
B S Basavarajappa, T V Gowda
Toxicon : Official Journal of the International Society on Toxinology
M K Bhat, T V Gowda
Toxicon : Official Journal of the International Society on Toxinology
M K BhatT V Gowda
Toxicon : Official Journal of the International Society on Toxinology
L M Rudrammaji, T V Gowda
© 2022 Meta ULC. All rights reserved