PMID: 9535276Apr 16, 1998Paper

Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes

Journal of Protein Chemistry
M G GiuffridaJ Godovac-Zimmermann

Abstract

We have isolated and characterized two proteins of 50 and 30 kDa from human milk fat globule membranes of healthy donors. N-terminal and internal sequencing revealed that the 50-kDa protein is the full-length human breast carcinoma protein BA46 that is highly expressed in human breast tumors. The 30-kDa protein is a truncated form of protein BA46 which consists of the C-terminal factor V/VIII-like domain of BA46 and which appears to anchor BA46 to the milk fat globule membrane. Defective release of the epidermal growth factor domain containing a surface RGD motif may be related to involvement of BA46 in breast cancer.

Citations

Oct 10, 2007·Biochemistry. Biokhimii︠a︡·A A Terentiev, N T Moldogazieva
Jan 16, 2009·International Journal of Immunopathology and Pharmacology·M G GiuffridaE Bertino
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·B HäggqvistP Westermark
Jul 14, 2005·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Siwei PengPer Westermark
Jun 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W Vogel
Oct 15, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhiliang WuYoichi Maekawa
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiujie ZhaoYanqing Li
Jun 3, 1999·Biochimica Et Biophysica Acta·W M CampanaS Patton

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