PMID: 6165073Jan 1, 1981Paper

Isolation and characterization of intermediate complexes and other components with common antigenic determinants

Scandinavian Journal of Immunology
U B HanssonU Alkner

Abstract

Fractions with affinity for heat-denatured human IgG (HDG) were isolated from four sera that contained intermediate complexes (IC). These IC fractions contained part of the 75 IgG, all IC, and part of the rapidly sedimenting complexes (RC) found in the sera. The IC consisted of IgG1 or IgG3 and the RC of IgG and IgM with kappa and lambda light chains. The IgG in the IC fractions contained an abnormally large amount of neuraminic acid. No correlation between IgG subclass or content of neuraminic aid and complex formation was found. There were indications that the formation of IC was not only the result of self-association of IgG molecules with anit-gamma-globulin activity. Specific rabbit antisera were prepared against two of the IC fractions. Affinity chromatography wtih immobilized IgG and F(ab')2gamma from these antisera confirmed the presence of common antigenic determinants in the sera. These determinants occurred mainly in 7S components in one individual, in IC in one and in RC in another. Only a minor part of the serum components with affinity for HDG contained the determinants. RF activity was found in the components that lacked and in those that contained the common antigenic determinants.

References

Mar 15, 1975·Lancet·P M JohnsonE J Wolborow
Mar 1, 1979·Scandinavian Journal of Immunology·O FørreJ B Natvig
Jan 1, 1978·Journal of Immunological Methods·U B Hansson, S Winblad
Jan 1, 1976·Annual Review of Microbiology·R G White
Jan 1, 1977·Scandinavian Journal of Rheumatology·O T ForreJ B Natvig
May 1, 1979·Arthritis and Rheumatism·J T HallaR E Schrohenloher
Oct 26, 1978·Nature·R R Porter, K B Reid
Jun 13, 1975·Annals of the New York Academy of Sciences·R J Winchester
Aug 1, 1976·Annals of the Rheumatic Diseases·P J Roberts-ThomsonA G Mowat
Feb 1, 1973·The Journal of Experimental Medicine·H G KunkelJ D Capra
Jul 1, 1974·Annals of the Rheumatic Diseases·P M JohnsonB M Tracey
Jan 1, 1974·The Journal of Experimental Medicine·H G KunkelJ D Capra
Jan 11, 1969·Nature·B FrangioneE C Franklin
Jan 1, 1970·Advances in Immunology·H Metzger
Jan 1, 1968·Acta Chemica Scandinavica·U B Hansson
Mar 1, 1961·Journal of General Microbiology·G L ADAP E LIND
Jan 1, 1961·The Journal of Clinical Investigation·H G KUNKELT B TOMASI
Apr 1, 1965·The Journal of Experimental Medicine·H M GREYH G KUNKEL

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Citations

Jan 1, 1988·Springer Seminars in Immunopathology·T W RademacherI Roitt
Jan 1, 1982·Molecular Immunology·U AlknerJ Glans
Oct 1, 1995·Scandinavian Journal of Immunology·K AnderssonU Alkner
Aug 1, 1983·Scandinavian Journal of Immunology·U Alkner
Jul 1, 1985·Scandinavian Journal of Immunology·U B HanssonF D Lindström

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