PMID: 6403846Mar 1, 1983Paper

Isolation and characterization of mitomycin-C-sensitive mouse lymphoma cell mutants

Mutation Research
H Hama-InabaK Sato

Abstract

26 mutants with increased sensitivity to the lethal effects of mitomycin C (MMC) were isolated from mouse lymphoma L5178Y cells by a replica-plating technique. Most of them were about 5-10 times more sensitive in terms of D37 values to MMC than were parental cells. 5 of the MMC-sensitive mutants isolated from independently mutagenized cell populations were further analyzed. They were highly sensitive to the killing by decarbamoyl (DC) MMC, a monofunctional derivative of MMC, but were not sensitive to ultraviolet radiation, X-rays, 4-nitroquinoline-1-oxide or methyl methanesulfonate. These 5 mutants were classified into at least 2 genetic complementation groups. The implication of these mutations in cross-link and mono-adduct repair of DNA damage induced by MMC and DCMMC is discussed.

References

Jan 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K Sato, N Hieda
Jul 15, 1977·Journal of Molecular Biology·Y Fujiwara, M Tatsumi
Jan 1, 1976·Cytogenetics and Cell Genetics·S Hashimi, O J Miller
Jul 23, 1975·Biochimica Et Biophysica Acta·D Averbeck, E Moustacchi
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R S Cole
Feb 1, 1968·Journal of Bacteriology·N Otsuji
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Feb 1, 1981·Mutation Research·J H FrazelleM Swift
Dec 1, 1981·Mutation Research·K Sato, R B Setlow
May 1, 1980·Somatic Cell Genetics·L H ThompsonK Brookman
Dec 30, 1964·Zeitschrift für Vererbungslehre·R P BOYCE, P HOWARD-FLANDERS

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Citations

Nov 1, 1990·Somatic Cell and Molecular Genetics·M Z ZdzienickaJ W Simons
Dec 1, 1984·Mutation Research·H P Leenhouts, K H Chadwick
Mar 1, 1989·Mutation Research·F Rosselli, E Moustacchi
Sep 27, 2012·DNA Repair·Larry H Thompson
Jan 1, 1989·Environmental and Molecular Mutagenesis·L H Thompson

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