PMID: 9171404Jun 1, 1997Paper

Isolation and characterization of multiple adenylate cyclase genes from the cyanobacterium Anabaena sp. strain PCC 7120

Journal of Bacteriology
M Katayama, Masayuki Ohmori

Abstract

Adenylate cyclase genes, designated cyaA, cyaB1, cyaB2, cyaC, and cyaD, were isolated from the filamentous cyanobacterium Anabaena sp. strain PCC 7120 by complementation of a strain of Escherichia coli defective for the presence of cya. These genes encoded polypeptides consisting of 735, 859, 860, 1,155, and 546 amino acid residues, respectively. Deduced amino acid sequences of the regions near the C-terminal ends of these cya genes were similar to those of catalytic domains of eukaryotic adenylate cyclases. The remaining part of each cya gene towards its N-terminal end showed a characteristic structure. CyaA had two putative membrane-spanning regions. Both CyaB1 and CyaB2 had regions that were very similar to the cyclic GMP (cGMP)-binding domain of cGMP-stimulated cGMP phosphodiesterase. CyaC consisted of four distinct domains forming sequentially from the N terminus: a response regulator-like domain, a histidine kinase-like domain, a response regulator-like domain, and the catalytic domain of adenylate cyclase. CyaD contained the forkhead-associated domain in its N-terminal region. Expression of these genes was examined by reverse transcription-PCR. The transcript of cyaC was shown to be predominant in this cyanobacterium. Th...Continue Reading

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Citations

Nov 24, 1999·Molecular Microbiology·K Cho, D R Zusman
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·A MoutinhoR Malhó
Jun 28, 2003·The Journal of Biological Chemistry·Martin J CannTobias Kanacher
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May 15, 2004·Environmental Microbiology·Michael Y Galperin
Jun 28, 2002·Molecular Microbiology·Hidehisa YoshimuraMasayuki Ohmori
May 12, 2007·Molecular Microbiology·Martin Cann
Mar 31, 2004·Molecular Microbiology·Kazuki Terauchi, Masayuki Ohmori
Feb 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sergio E MartinezJürgen U Linder
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