Isolation and characterization of several plasma apolipoproteins of common marmoset monkey

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
D CrookR W Mahley

Abstract

To explore the potential of the common marmoset monkey (Callithrix jacchus) as a model for human plasma lipoprotein metabolism, several marmoset apolipoproteins were isolated and characterized in this study. Based on several properties, including molecular weight, amino acid composition, and sequence, the marmoset apolipoproteins are strikingly similar to human apolipoprotein (apo) A-I, A-II, C-III, and A-IV. The first 54 residues of marmoset apo A-I showed 87% sequence identity with the corresponding region of human apo A-I. Amino-terminal sequence analysis of a minor basic apo A-I isoform revealed that it contained an amino-terminal hexapeptide extension (Arg-His-Phe-Gln-Gln-) identical to that found in human proapo A-I. Like apo A-II in most nonhuman primates, marmoset apo-A-II differed from human apo A-II in that it did not contain cysteine and therefore existed as a monomer. The complete amino acid sequence of marmoset apo A-II was deduced. The protein contains 77 amino acids, as does human apo A-II, and showed an 82% identity with its human equivalent. In both species, apo C-III and E had similar amino-terminal sequences and amino acid compositions. Like human apo E, marmoset apo E contained minor sialylated isoforms. How...Continue Reading

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Citations

Mar 20, 1993·Biochimica Et Biophysica Acta·J OsadaJ M Ordovás
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D CrookR W Mahley
Jun 13, 2002·The Journal of Toxicological Sciences·Ikuo HoriiKeitaro Hashimoto
Jun 13, 2006·Journal of Medical Primatology·Srebrena AtanasovaVictor Armstrong
Dec 1, 2009·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Donald L PuppioneJulian P Whitelegge
Jan 1, 1993·Progress in Lipid Research·E I Mercer
Jan 1, 1993·Progress in Lipid Research·K E Suckling, B Jackson
Jul 16, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Donald L PuppioneMelinda H MacDonald

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