Isolation and characterization of sodium 2-fluoroacetate from Mascagnia rigida using chromatography and infrared spectroscopy

Toxicon : Official Journal of the International Society on Toxinology
Luciana Castro da CunhaSilvana L Górniak

Abstract

Sodium monofluoroacetate was first identified in Dichapetalum cymosum, a South African plant that can cause livestock poisoning and death. After, several other plants also showed to contain this toxin, which leads to the "sudden death". Mascagnia rigida, a well identified poisonous plant, commonly found in northeast of Brazil also cause sudden death in cattle, which shows clinical signs similar to those produced by the ingestion of plants that contain monofluoroacetate. Our aim was to identify the toxic compound present in the aqueous extract of M. rigida. For this purpose, the dried and milled plant was extracted; the extract was lyophilized and submitted to successive chromatographic process, until the desired purity of the active compound was achieved. The study of this material by planar chromatography and by infrared spectrometry indicated that the toxin can be a mixture of mono, di and trifluoroacetate.

References

Nov 30, 2002·Toxicon : Official Journal of the International Society on Toxinology·Carlos Hubinger TokarniaPaulo Vargas Peixoto
Aug 27, 2005·Australian Veterinary Journal·C S S GohN Malikides

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Citations

Nov 26, 2015·Toxicon : Official Journal of the International Society on Toxinology·Fabricio K de L CarvalhoFranklin Riet-Correa
Feb 13, 2013·Journal of Applied Toxicology : JAT·Amélia L L DuarteFranklin Riet-Correa
Jan 21, 2014·Toxicon : Official Journal of the International Society on Toxinology·Daniel CookDale R Gardner
Jan 5, 2017·Critical Reviews in Biotechnology·Maria F Carvalho, Rui S Oliveira

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