Jan 21, 1976

Isolation and characterization of the brush border fraction from newborn rat renal proximal tubule cells

Biochimica Et Biophysica Acta
D R GoldmannS Segal


A renal brush border fraction was isolated from newborn Sprague-Dawley rats, and its morphological and enzymatic characteristics were studied in comparison to that from the adult. Definite microvillar structures are seen by electron microscopy, and border preparations from the newborn are enriched in known marker enzymes. Though morphological development is more advanced and enzyme specific activities are greater in the adult, polyacrylamide gel electrophoresis of membrane proteins reveals no significant change in pattern with increasing age. These studies suggest that the brush border of the proximal tubule cell is present at birth as a significantly developed structure.

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Mentioned in this Paper

Enzymes, antithrombotic
Succinate Dehydrogenase
Gamma-glutamyl transferase
Methoxyleucine Aminopeptidase
Alkaline Phosphatase
Brush border antigen
Rats, Sprague-Dawley

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