PMID: 8962151Dec 10, 1996Paper

Isolation and characterization of the chicken m2 acetylcholine receptor promoter region: induction of gene transcription by leukemia inhibitory factor and ciliary neurotrophic factor

Proceedings of the National Academy of Sciences of the United States of America
M RosoffNeil M Nathanson

Abstract

We have isolated the promoter region and determined the start sites of transcription for the gene encoding the chicken m2 (cm2) muscarinic acetylcholine receptor. Transfection experiments, using cm2-luciferase reporter gene constructs, demonstrated that a 789-bp genomic fragment was sufficient to drive high level expression in chicken heart primary cultures, while an additional 1.2-kb region was required for maximal expression in mouse septal/ neuroblastoma (SN56) cells. Treatment of SN56 cells with the cytokines ciliary neurotrophic factor and leukemia inhibitory factor increases expression of endogenous muscarinic acetylcholine receptors and results in a 4- to 6-fold induction of cm2 promoter driven luciferase expression. We have mapped a region of the cm2 promoter that is necessary for induction by cytokines.

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Citations

Dec 13, 2006·Behavior Genetics·Danielle M DickLaura Bierut
Mar 9, 1999·Life Sciences·D SaffenT Haga
Sep 24, 1998·Trends in Pharmacological Sciences· Haddad el-B, J Rousell
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Aug 9, 2016·Trends in Molecular Medicine·Chanan MeydanHermona Soreq
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Jul 4, 1997·The Journal of Biological Chemistry·S PepitoniN J Buckley
Apr 26, 2021·Research in Veterinary Science·Caroline SchoellerGetu Abraham

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