PMID: 2508059Sep 25, 1989Paper

Isolation and characterization of the Drosophila translational elongation factor 2 gene

Nucleic Acids Research
Y GrinblatF C Kafatos

Abstract

We have isolated a cDNA clone that encodes the Drosophila melanogaster elongation factor 2 (EF2), a protein involved in the elongation step of protein synthesis. This identification was based on the high degree of its amino acid sequence identity (greater than 80%) to that of hamster EF2. The gene encoding Drosophila EF2 is found at position 39E-F of the 2L chromosomal arm and maybe identical to the M(2)H locus, which produces a Minute phenotype when mutated. The genomic organization of the locus includes four exons. Conserved sequence segments shared with a variety of GTP binding proteins are found in the amino terminal third of the protein, and segments unique to EF2 and its prokaryotic functional homolog, EF-G, are in the carboxy terminal half; these two regions are segregated in two respective exons.

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Citations

Apr 1, 1995·Molecular and Biochemical Parasitology·D E JonesD P Clark
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·R CretiP Cammarano
Jun 11, 1993·Nucleic Acids Research·C BarkerP N Tsichlis
Apr 15, 1993·European Journal of Biochemistry·N T RedpathC G Proud
Feb 19, 2013·Insect Biochemistry and Molecular Biology·Hervé ColinetJesper Givskov Sørensen
Aug 6, 2016·Fly·Steven J MarygoldPaul Lasko
May 1, 2001·DNA Sequence : the Journal of DNA Sequencing and Mapping·A KatoY Komeda
Sep 24, 1992·Biochimica Et Biophysica Acta·G RaimoV Bocchini

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