Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae)

Toxicon : Official Journal of the International Society on Toxinology
K HaradaW W Carmichael

Abstract

Two structurally similar analogues of microcystins LR and RR, cyclic peptide hepatotoxins from Microcystis, were isolated by chromatographic methods. Although they have the same mol. wt and amino acid compositions as those of the parent toxins, they do not possess similar toxicities. Ultraviolet and 1H-NMR spectral data for both components demonstrate clear structural difference of these cyclic peptides from the parent toxins, which are probably responsible for the marked decreases in their observed toxicities.

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Citations

Oct 12, 2001·Environmental Toxicology·M ReinikainenK Harada
May 26, 2011·Biodegradation·A RamaniK Jayachandran
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·K HaradaM Nakano
Nov 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·M NamikoshiK L Rinehart
Mar 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·F KondoM Suzuki
Jun 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·R R StottsV R Beasley
Jan 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·R LuukkainenS I Niemelä
Jun 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·J M Delaney, R M Wilkins
Dec 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·K TsujiK I Harada
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Jussi MeriluotoSeppo Salminen
May 2, 2001·Journal of Chromatography. a·L A Lawton, C Edwards
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