Isolation and characterization of the TERE1 gene, a gene down-regulated in transitional cell carcinoma of the bladder

Oncogene
Terence W McGarveyS Bruce Malkowicz

Abstract

We have identified a novel cDNA product designated transitional epithelial response gene (TERE1), which was localized to chromosome 1p36. The TERE1 transcript (1.5 and 3.5 kb) is present in most normal human tissues including urothelium, but was reduced or absent in the majority of muscle invasive TCC tumors (22 out of 29 cases). The open reading frame encodes a protein of 338 amino acids (MW 36.8 KD). This protein is 57% homologous to a Drosophila protein called heix. We have shown by Western blotting and immuno-histochemistry with a polyclonal antibody to a specific TERE1 peptide, reduced or absent staining in muscle invasive tumors. Transfection of a sense TERE1 construct resulted in an 80-90% inhibition of cellular proliferation in two TCC cell lines and a lack of aneuploidy in the TERE1-transduced J82 cell line. These data suggest a potential role for this gene product in the progression of bladder cancer.

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Citations

Jan 28, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Cordula M StoverWilhelm J Schwaeble
Aug 27, 2013·PloS One·Xian WangLing Hong
Mar 23, 2005·Journal of Cellular Biochemistry·Terence W McGarveyS Bruce Malkowicz
Apr 9, 2013·Journal of Cellular Biochemistry·William J FredericksS Bruce Malkowicz
Jan 1, 2010·Cell Biology International Reports·Yanzhi XiaLing Hong
Dec 24, 2002·The Prostate·Terence W McGarveyS Bruce Malkowicz
Mar 17, 2015·Biochemical and Biophysical Research Communications·Nobuaki FunahashiToshio Okano
Aug 2, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshio Okano
Dec 8, 2017·Scientific Reports·Maytham A DraghLing Hong
Jun 2, 2018·Annual Review of Nutrition·Martin J Shearer, Toshio Okano
Nov 30, 2018·Molecular Medicine Reports·Bingju Yan, Jun Wang
Jun 22, 2021·Annual Review of Biochemistry·Marc M Schumacher, Russell A DeBose-Boyd
Aug 10, 2021·Molecular Medicine Reports·Jumin Xie, Lingxing Li

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