PMID: 4321893Nov 1, 1970

Isolation and characterization of three phosphoamido-neomycins and their conversion into neomycin by Streptomyces fradiae

The Biochemical Journal
M K Majumdar, S K Majumdar

Abstract

Some amino acids, particularly glycine and serine, favour the accumulation in the fermentation broth of three phosphorylated amino sugar compounds that are intermediates in the pathway of neomycin biosynthesis by Streptomyces fradiae 3535. The compounds were separated and purified further by Amberlite IRC-50 (NH(4) (+) form). The intermediates were characterized by physicochemical methods as neomycin B pyrophosphate (C(23)H(48)N(6)O(19)P(2),3H(2)O), neomycin C pyrophosphate (C(23)H(48)N(6)O(19)P(2),3H(2)O) and neomycin C dipyrophosphate complex (C(24)H(66)N(8)O(33)P(4)).

Related Concepts

Quaternary Ammonium Compounds
Paper Chromatography (Procedure)
Glycine, Monopotasssium Salt
Neomycin Palmitate
Diphosphates
Serine
Streptomyces

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