PMID: 377008Jan 10, 1979Paper

Isolation and characterization of yeast mutants auxotrophic for 2'-deoxythymidine 5'-monophosphate

Molecular & General Genetics : MGG
J G Little, R H Haynes

Abstract

Mutant strains of Saccharomyces cerevisiae auxotrophic for deoxythymidine monophosphate (dTMP) were isolated and characterized. Two distinct classes of auxotrophs were obtained. One class had a simple requirement for dTMP and was analogous to thymine-requiring bacteria. The second class required dTMP, adenine, histidine and methionine and this complex nutritional phenotype was due to defects in folate metabolism. The dTMP-dependent growth of respiratory-competent grande auxotrophs was found to be markedly affected by media composition and carbon source. In the absence of dTMP thymineless death occurred in both mutant classes.

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Citations

Jul 9, 1999·Environmental and Molecular Mutagenesis·B A Kunz, P C Hanawalt
Apr 25, 2000·Archives of Biochemistry and Biophysics·L DeSouzaA L Bognar
Jan 1, 1981·Chromosoma·P B MoensJ G Little
Jan 1, 1981·Molecular & General Genetics : MGG·J B McNeil, J D Friesen
Jan 1, 1986·Current Genetics·E M McIntoshR H Haynes
Jul 1, 1988·Mutation Research·R H Haynes, B A Kunz
Sep 1, 1993·Mutation Research·S E Kohalmi, B A Kunz
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B A KunzR H Haynes
Jun 1, 2004·Molecular Biology of the Cell·Ulrich GüldenerJohannes H Hegemann
Oct 25, 2003·Nucleic Acids Research·Jeffrey A HodsonSusan L Forsburg
Jan 19, 1999·Annual Review of Microbiology·S I AhmadA Eisenstark
Nov 1, 1991·International Journal of Radiation Biology·N UsamiS Ishizaka
Feb 12, 2008·Nucleic Acids Research·Arturas MeskauskasJonathan D Dinman
Oct 9, 2019·Cells·Sergey O Sulima, Jonathan D Dinman
Jan 1, 1982·Environmental Mutagenesis·B A Kunz
Feb 12, 1998·Methods : a Companion to Methods in Enzymology·C H SibleyB Kilbey
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Oct 1, 1982·Journal of Bacteriology·L F Bisson, J Thorner
Dec 1, 1984·Molecular and Cellular Biology·R K StormsM Belfort
Apr 1, 1982·Molecular and Cellular Biology·R Zelikson, M Luzzati

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