PMID: 3473468Jun 1, 1987Paper

Isolation and complete amino acid sequence of human thymopoietin and splenin

Proceedings of the National Academy of Sciences of the United States of America
T K AudhyaG Goldstein

Abstract

Human thymopoietin and splenin were isolated from human thymus and spleen, respectively, by monitoring tissue fractionation with a bovine thymopoietin RIA cross-reactive with human thymopoietin and splenin. Bovine thymopoietin and splenin are 49-amino acid polypeptides that differ by only 2 amino acids at positions 34 and 43; the change at position 34 in the active-site region changes the receptor specificities and biological activities. The complete amino acid sequences of purified human thymopoietin and splenin were determined and shown to be 48-amino acid polypeptides differing at four positions. Ten amino acids, constant within each species for thymopoietin and splenin, differ between the human and bovine polypeptides. The pentapeptide active site of thymopoietin (residues 32-36) is constant between the human and bovine thymopoietins, but position 34 in the active site of splenin has changed from glutamic acid in bovine splenin to alanine in human splenin, accounting for the biological activity of the human but not the bovine splenin on the human T-cell line MOLT-4.

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Citations

Sep 1, 1996·Journal of Peptide Science : an Official Publication of the European Peptide Society·E Bolewska-PedyczakZ Wieczorek
Jun 1, 1989·Cellular and Molecular Neurobiology·E L OchoaM G McNamee
Oct 1, 1992·Journal of the Neurological Sciences·B EymardS Berrih-Aknin
Jul 20, 1988·Biochimica Et Biophysica Acta·A A AmoscatoG F Babcock
Jul 4, 2002·Immunology Letters·Ranjna C Dutta
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M QuikG Goldstein
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·G GoldsteinT Audhya
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·C A HarrisG Goldstein
Jan 1, 1988·Annals of the New York Academy of Sciences·T K Audhya, G Goldstein
Jan 1, 1992·International Journal of Peptide and Protein Research·H Kessler, B Haase
Aug 1, 1994·International Journal of Peptide and Protein Research·D D SmithB J Morley
Mar 1, 1991·International Journal of Peptide and Protein Research·G A HeavnerG Goldstein

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