PMID: 9540826Apr 16, 1998Paper

Isolation and expression of a human SRY-related cDNA hSOX20

Biochimica Et Biophysica Acta
Y HiraokaS Aiso

Abstract

SOX is a family of genes related to the testis-determining gene, SRY. We have isolated and sequenced an hSOX20 cDNA from a cell line of human embryonic carcinoma. This cDNA contains an open reading frame (ORF) encoding 233 amino acids. The protein encompasses an SRY-type HMG box exhibiting strong homologies to those of mouse Sox15 and Sox16. Various adult and fetal tissues were tested for hSOX20 mRNA by Northern analysis. Its expression is restricted to the fetal testis and the size of the transcript is 1.5 knt. Electrophoretic mobility shift assay indicated that recombinant hSOX20 polypeptide is capable of binding to AACAAT sequence.

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Citations

Aug 2, 2003·Biochimica Et Biophysica Acta·Jun HagiudaSadakazu Aiso
Aug 14, 2003·Gene Expression Patterns : GEP·Mai A SarrajAndrew H Sinclair
Jan 13, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yuich OkudaYusuke Kamachi
Jun 27, 2007·The Tohoku Journal of Experimental Medicine·Wei ChenMo-Yi Sun
May 24, 2000·The Journal of Biological Chemistry·F BérangerM Vandromme

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