PMID: 19912877Aug 1, 1992Paper

Isolation and expression of the Drosophila drosulfakinin neural peptide gene product, DSK-I

Molecular and Cellular Neurosciences
Ruthann Nichols

Abstract

The Drosophila drosulfakinin (dsk) gene encodes the cholecystokinin homologues drosulfakinin-I (DSK-I) and drosulfakinin-II (DSK-II). The naturally occurring DSKI peptide was isolated from an extract of adult flies and its sequence determined by automated Edman degradation and sequence-specific radioimmunoassay. The dsk cDNA is expressed during the larval, pupal, and adult stages of development and is an abundant adult head transcript. Sequence-specific DSK antibodies localized DSK expression in the Drosophila larval central nervous system to medial neurosecretory cells and projections that extend from the neurons anteriorly into the brain and posteriorly down the ventral ganglion. The availability of the dsk transcript, sequence-specific DSK antibodies and the application of molecular genetics provide the opportunity to elucidate the role(s) of Drosophila CCK homologues in brain structure and function.

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Citations

Feb 16, 2002·Biochemical and Biophysical Research Communications·Teresa M KubiakDavid E Lowery
Apr 1, 1994·Cell and Tissue Research·Y ChenH H Hagedorn
Feb 17, 2000·Annals of the New York Academy of Sciences·R NicholsI A Lim
Feb 15, 2012·The Journal of Cell Biology·Xu Chen, Barry Ganetzky
Jun 20, 2000·Journal of Neurogenetics·R NicholsC Rosario
Sep 9, 2008·General and Comparative Endocrinology·N Audsley, R J Weaver
Jun 11, 1999·Journal of Neurobiology·R NicholsI Lim
Jun 5, 1998·International Journal of Nursing Practice·U M Edéll-GustafssonE K Hamrin
Jan 5, 2020·The Journal of Experimental Biology·Pavan AgrawalLoren L Looger
Jan 25, 2000·Archives of Insect Biochemistry and Physiology·J A Veenstra
Jun 19, 2007·The Journal of Experimental Biology·Patsy S DickinsonAndrew E Christie
Dec 8, 1993·The Journal of Comparative Neurology·J McCormick, R Nichols

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