PMID: 6547228Apr 27, 1984Paper

Isolation and identification of 4-hydroxysulfamerazine and preliminary studies on its pharmacokinetics in dogs

Pharmaceutisch Weekblad. Scientific Edition
T B VreeY A Hekster


For the following compounds: sulfamerazine, 4- hydroxysulfamerazine , N4- acetylsulfamerazine , N4-acetyl-4- hydroxysulfamerazine , the following data are reported: biosynthesis in the dog, isolation, identification by MS and NMR, TLC (Rf values) and HPLC (capacity factors and molar extinction), half-life of elimination, metabolism, renal excretion and protein binding in dog. Dogs are unable to acetylate sulfamerazine, but eliminate predominantly by hydroxylation of the N1-substituent. Administered N4- acetylsulfamerazine is predominantly eliminated by deacetylation to sulfamerazine which in turn is hydroxylated. The renal clearances of sulfamerazine and N4- acetylsulfamerazine in the dog are identical. The renal excretion of both compounds proceeds by the passive processes of glomerular filtration and tubular reabsorption. 4- Hydroxysulfamerazine and its glucuronide have a higher renal clearance than sulfamerazine.


Jul 1, 1979·Clinical Pharmacokinetics·T B VreeW J O'Reilly
Mar 1, 1975·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Atef, P Nielsen
Dec 1, 1973·The Biochemical Journal·P Nielsen
Jan 1, 1965·Journal of Theoretical Biology·A Despopoulos
Jun 1, 1983·Journal of Veterinary Pharmacology and Therapeutics·T B VreeJ F Nouws
Jan 1, 1982·Antibiotics and Chemotherapy·C A Hekster, T B Vree
Jan 1, 1981·British Journal of Clinical Pharmacology·K K MidhaP K Yeung
Nov 1, 1944·The Journal of Clinical Investigation·D P Earle
May 17, 1940·Science·J V Scudi


Apr 24, 1987·Pharmaceutisch Weekblad. Scientific Edition·J F NouwsT B Vree
Jun 1, 1986·Veterinary Immunology and Immunopathology·J L GrondelO L Haenen
Dec 1, 1994·The Journal of Pharmacy and Pharmacology·T Nagata, Y Fukuda
Jan 1, 1985·The Veterinary Quarterly·J F NouwsY A Hekster
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Sep 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·W YounanM Degen
Sep 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·J F NouwsJ Holtkamp
Mar 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·J F NouwsT B Vree

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