PMID: 6547228Apr 27, 1984Paper

Isolation and identification of 4-hydroxysulfamerazine and preliminary studies on its pharmacokinetics in dogs

Pharmaceutisch Weekblad. Scientific Edition
T B VreeY A Hekster

Abstract

For the following compounds: sulfamerazine, 4- hydroxysulfamerazine , N4- acetylsulfamerazine , N4-acetyl-4- hydroxysulfamerazine , the following data are reported: biosynthesis in the dog, isolation, identification by MS and NMR, TLC (Rf values) and HPLC (capacity factors and molar extinction), half-life of elimination, metabolism, renal excretion and protein binding in dog. Dogs are unable to acetylate sulfamerazine, but eliminate predominantly by hydroxylation of the N1-substituent. Administered N4- acetylsulfamerazine is predominantly eliminated by deacetylation to sulfamerazine which in turn is hydroxylated. The renal clearances of sulfamerazine and N4- acetylsulfamerazine in the dog are identical. The renal excretion of both compounds proceeds by the passive processes of glomerular filtration and tubular reabsorption. 4- Hydroxysulfamerazine and its glucuronide have a higher renal clearance than sulfamerazine.

References

Jul 1, 1979·Clinical Pharmacokinetics·T B VreeW J O'Reilly
Mar 1, 1975·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Atef, P Nielsen
Dec 1, 1973·The Biochemical Journal·P Nielsen
Jan 1, 1965·Journal of Theoretical Biology·A Despopoulos
Jun 1, 1983·Journal of Veterinary Pharmacology and Therapeutics·T B VreeJ F Nouws
Jan 1, 1982·Antibiotics and Chemotherapy·C A Hekster, T B Vree
Jan 1, 1981·British Journal of Clinical Pharmacology·K K MidhaP K Yeung
Nov 1, 1944·The Journal of Clinical Investigation·D P Earle
May 17, 1940·Science·J V Scudi

Citations

Apr 24, 1987·Pharmaceutisch Weekblad. Scientific Edition·J F NouwsT B Vree
Jun 1, 1986·Veterinary Immunology and Immunopathology·J L GrondelO L Haenen
Dec 1, 1994·The Journal of Pharmacy and Pharmacology·T Nagata, Y Fukuda
Jan 1, 1985·The Veterinary Quarterly·J F NouwsY A Hekster
Oct 30, 1992·Journal of Chromatography·D GuggisbergH Koch
Sep 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·W YounanM Degen
Sep 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·J F NouwsJ Holtkamp
Mar 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·J F NouwsT B Vree

Related Concepts

N(4)-acetylsulfamerazine
4-hydroxysulfamerazine
N-4-acetyl-4-hydroxysulfamerazine
High Pressure Liquid Chromatography Procedure
Thin Layer Chromatography
Canis familiaris
Kidney
Plasma Protein Binding Capacity
Mebacid

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.