PMID: 38311Jul 1, 1979

Isolation and identification of a fluorophore from ampicillin degradation

The Journal of Pharmacy and Pharmacology
M J LebelleW L Wilson


A fluorescent impurity in ampicillin has been isolated and identified as 2-hydroxy-3-phenylpyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis.


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Oct 1, 1976·The Journal of Pharmacy and Pharmacology·R H Barbhaiya, P Turner
Sep 1, 1977·The Journal of Antimicrobial Chemotherapy·R H Barbhaiya, P Turner
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Jun 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·R H BarbhaiyaE Shaw
Jul 1, 1977·Journal of Medicinal Chemistry·J M IndelicatoW L Wilham
Jul 1, 1977·Journal of Medicinal Chemistry·A Dinner
Aug 1, 1977·British Journal of Clinical Pharmacology·R H Barbhaiya, P Turner
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Dec 1, 1974·The Journal of Antibiotics·T YamanaO Nakano
Sep 1, 1973·Journal of Pharmaceutical Sciences·A I CohenM S Puar
Jun 1, 1969·Journal of Pharmaceutical Sciences·M A Schwartz
May 1, 1971·Journal of Pharmaceutical Sciences·W J Jusko
Apr 1, 1969·Journal of Pharmaceutical Sciences·J P Hou, J W Poole
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