PMID: 38311Jul 1, 1979

Isolation and identification of a fluorophore from ampicillin degradation

The Journal of Pharmacy and Pharmacology
M J LebelleW L Wilson

Abstract

A fluorescent impurity in ampicillin has been isolated and identified as 2-hydroxy-3-phenylpyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis.

References

Mar 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·S W BaertschiL J Lorenz
Mar 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·Y ZhuJ Hoogmartens
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·L N RodriguesA G Fogg
Nov 5, 1997·The Journal of Pharmacy and Pharmacology·V A Robinson-FuentesS K Branch

Citations

Oct 1, 1976·The Journal of Pharmacy and Pharmacology·R H Barbhaiya, P Turner
Sep 1, 1977·The Journal of Antimicrobial Chemotherapy·R H Barbhaiya, P Turner
Apr 1, 1978·The Journal of Pharmacy and Pharmacology·R H BarbhaiyaP Turner
Jun 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·R H BarbhaiyaE Shaw
Jul 1, 1977·Journal of Medicinal Chemistry·J M IndelicatoW L Wilham
Jul 1, 1977·Journal of Medicinal Chemistry·A Dinner
Aug 1, 1977·British Journal of Clinical Pharmacology·R H Barbhaiya, P Turner
Aug 1, 1974·Chemical & Pharmaceutical Bulletin·K MiyazakiT Arita
Dec 1, 1974·The Journal of Antibiotics·T YamanaO Nakano
Sep 1, 1973·Journal of Pharmaceutical Sciences·A I CohenM S Puar
Jun 1, 1969·Journal of Pharmaceutical Sciences·M A Schwartz
May 1, 1971·Journal of Pharmaceutical Sciences·W J Jusko
Apr 1, 1969·Journal of Pharmaceutical Sciences·J P Hou, J W Poole
Jan 1, 1949·Journal of the American Chemical Society·R G JONES

Related Concepts

Pyrazines
Fluorescence Spectroscopy
Fluorescent stain
High Pressure Liquid Chromatography Procedure
Drug Stability
Acids
Catabolism
Assay
Ukapen
Ampicillin

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