Isolation and identification of Malassezia species from Chinese and Korean patients with seborrheic dermatitis and in vitro studies on their bioactivity on sebaceous lipids and IL-8 production

Mycoses
Soo Young KimKyu Joong Ahn

Abstract

We investigated the distribution of Malassezia yeast in 120 Chinese (20 patients from each of six cities) and 20 Korean patients with scalp seborrheic dermatitis (SD) and dandruff (SD/D) using ITS1 and ITS2 polymerase chain reaction-restriction fragment length polymorphism. Bioactivity was studied by quantifying sebum lipid production by human primary sebocytes and inflammatory cytokine, interleukin-8 (IL-8) production was studied by exposing HaCaT keratinocytes with extracts of five standard Malassezia strains; M. globosa, M. restricta, M. sympodialis, M. dermatis and M. slooffiae. M. restricta and M. globosa were the most frequently encountered species from both Chinese and Korean patients. These two Malassezia species also promoted neutral lipid synthesis although the result was not statistically significant and induced significant increase in IL-8 production among the five Malassezia species studied. The study suggests a possible role of these organisms in the pathogenesis of SD/D.

References

Jun 1, 1975·The Journal of Investigative Dermatology·K J McGinleyA M Kligman
May 1, 1985·Journal of the American Academy of Dermatology·R B SkinnerE W Rosenberg
Jan 1, 1997·Mycoses·J Faergemann
Nov 9, 2000·The British Journal of Dermatology·V Crespo ErchigaF Sanchez Fajardo
May 12, 2001·The Journal of Investigative Dermatology·S WatanabeA Hasegawa
Nov 4, 2004·Journal of the American Academy of Dermatology·Aditya K GuptaThomas L Dawson
Aug 9, 2005·FEMS Yeast Research·Roma BatraAditya K Gupta
Nov 12, 2005·Archives of Dermatological Research·Adone BaroniElisabetta Buommino
Dec 31, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Byung In Ro, Thomas L Dawson
Dec 31, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Yvonne M DeAngelisThomas L Dawson
Oct 31, 2006·FEMS Immunology and Medical Microbiology·Yoshio IshibashiAkemi Nishikawa
Apr 27, 2007·The Journal of Investigative Dermatology·Yvonne M DeAngelisThomas L Dawson
Oct 6, 2007·The British Journal of Dermatology·Y TakahataM Muto
Aug 30, 2008·FEMS Immunology and Medical Microbiology·Daniel S ThomasKeith T Holland
Dec 25, 2010·International Journal of Dermatology·Kathy KerrKevin J Mills
Jun 24, 2011·The Journal of Investigative Dermatology·Anelvi Patiño-UzcáteguiAdriana Celis
Jul 13, 2011·Annals of Dermatology·Yang Won LeeJae Sung Hwang
Jan 11, 2012·Clinical Microbiology Reviews·Georgios GaitanisAristea Velegraki
Jun 29, 2013·Clinics in Dermatology·Georgios GaitanisIoannis D Bassukas

❮ Previous
Next ❯

Citations

Mar 16, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·A K Gupta, S G Versteeg
Dec 8, 2017·Frontiers in Immunology·Florian Sparber, Salomé LeibundGut-Landmann
Mar 29, 2020·Bioprocess and Biosystems Engineering·Qingbin LinWei Chen
Mar 4, 2020·Experimental Dermatology·Jonas A AdalsteinssonJonathan Ungar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.