PMID: 4791491Nov 1, 1973

Isolation and identification of minor components of commercial kanamycin

Antimicrobial Agents and Chemotherapy
P J ClaesF Compernolle

Abstract

A fraction enriched in the minor components of the kanamycin complex was prepared from a commercial sample. The enriched fraction was subjected to Amberlite CG-50 and Dowex 1-X2 column chromatography. Two minor components were isolated in addition to the known A, B, and C components. These congeners were identified as paromamine and 6-o-(3-amino-3-deoxy-alpha-d-glucopyranosyl)- deoxystreptamine. The identification was based on degradation and mass spectral studies.

Related Concepts

Chromatography
Thin Layer Chromatography
Cyclohexanol
Cyclohexylamine
Hexosamines
Kantrex
Mass Spectrometry

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