Isolation and identification of the 3-hydroxy-5-hydroxymethyl-pyridinium compound as a novel advanced glycation end product on glyceraldehyde-related Maillard reaction

Bioscience, Biotechnology, and Biochemistry
Teruyuki Usui, Fumitaka Hayase

Abstract

Glyceraldehyde (200 mM) and N alpha-acetyllysine (100 mM) were incubated in 0.2 M sodium phosphate buffer (pH 7.4) at 37 degrees C for a week. A major compound, glyceraldehyde-related Maillard reaction product, was purified from the reaction mixture using reverse phase (ODS)-HPLC. It was identified as 1-(5-acetylamino-5-carboxypentyl)-3-hydroxy-5-hydroxymethyl-pyridinium, named as GLAP (Glyceraldehyde derived Pyridinium compound), using NMR and MS analyses. It was suggested that GLAP as a novel advanced glycation end product (AGE) is one of the key compounds in the glyceraldehyde-related Maillard reaction.

References

Jan 1, 1997·Experimental Neurology·C E Finch, D M Cohen
Oct 20, 1998·The American Journal of Pathology·N SasakiZ Makita
Dec 30, 1998·Journal of Neural Transmission·C LoskeG Münch
Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·R Lehmann, E D Schleicher
Aug 18, 2000·Free Radical Biology & Medicine·J W Baynes, S R Thorpe

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Citations

Feb 26, 2004·Bioscience, Biotechnology, and Biochemistry·Teruyuki UsuiFumitaka Hayase
Jun 24, 2006·Bioscience, Biotechnology, and Biochemistry·Teruyuki UsuiFumitaka Hayase
Sep 11, 2007·Bioscience, Biotechnology, and Biochemistry·Teruyuki UsuiFumitaka Hayase
Feb 8, 2008·Bioscience, Biotechnology, and Biochemistry·Teruyuki UsuiFumitaka Hayase
Jul 23, 2005·Annals of the New York Academy of Sciences·Fumitaka HayaseHirohito Watanabe
Dec 15, 2007·Annals of the New York Academy of Sciences·Fumitaka HayaseHirohito Watanabe
Jul 28, 2006·American Journal of Alzheimer's Disease and Other Dementias·Takashi SatoMasayoshi Takeuchi
Mar 10, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Masayoshi TakeuchiSho-ichi Yamagishi
Mar 2, 2019·Bioscience, Biotechnology, and Biochemistry·Shiori FujimotoHirohito Watanabe
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xueqian SuYun Yin
Jan 11, 2018·Bioscience, Biotechnology, and Biochemistry·Yoto MurakamiHirohito Watanabe
Mar 23, 2021·Biochemistry and Biophysics Reports·Tomoaki ShigetaTetsuro Yamamoto
Apr 4, 2021·Biomolecules·Masayoshi TakeuchiTamihide Matsunaga

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