Isolation and Identification of the Anti-Oxidant Constituents from Loropetalum chinense (R. Brown ) Oliv. Based on UHPLC⁻Q-TOF-MS/MS

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Haifang ChenShilin Yang

Abstract

The aim of this study was to identify the chemical constituents of Loropetalum chinense (R. Brown) Oliv. (LCO) and determine which of these had antioxidant effects. The chemical composition of a 70% ethanol extract of LCO was analyzed systematically using UHPLC⁻Q-TOF-MS/MS. The chemical components of the 70% ethanol extract of LCO were then separated and purified using macroporous resin and chromatographic techniques. Antioxidant activity was evaluated using a DPPH assay. In total, 100 compounds were identified tentatively, including 42 gallic acid tannins, 49 flavones, and 9 phenolic compounds. Of these, 7 gallium gallate, 4 flavonoid and 8 quinic acid compounds were separated and purified from the 70% ethanol extract of LCO. The compounds identified for the first time in LCO and in the genus Loropetalum were 3,4,5-trimethoxyphenyl-(6'-O-galloyl)-O-β-d-glucopyranoside, protocatechuic acid, ethyl gallate, 5-O-caffeoylquinic acid, 3-O-caffeoylquinic acid, 3,5-O-diocaffeoylquinic acid, 4,5-O-diocaffeoylquinic acid and 3,4-O-diocaffeoylquinic acid. The 50% inhibitory concentration (IC50) values of compounds 1,2,3,4,6-penta-O-galloyl-β-d-glucose, gallic acid, protocatechuic acid, and ethyl gallate were 1.88, 1.05, 1.18, and 1.05 μg...Continue Reading

References

May 26, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingchuan LiuSong Yang
Jul 3, 2016·BMC Complementary and Alternative Medicine·Kun LiShouyu Wang
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasmine ChemamFadila Benayache
Jun 11, 2017·International Journal of Biological Macromolecules·Hadi Hashemi Gahruie, Mehrdad Niakousari
Sep 30, 2017·Food Chemistry·Michalina GrzesikIzabela Sadowska-Bartosz
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lanlan ShanYubo Li
Jan 1, 2016·Reactive Oxygen Species·Hong ZhuY Robert Li
May 8, 2018·Pflügers Archiv : European journal of physiology·Masahito MiuraChiyohiko Shindoh
May 11, 2018·Mucosal Immunology·Gabriella Aviello, Ulla G Knaus
May 11, 2018·Journal of Diabetes Research·Ying-Hua ChenBo Feng

❮ Previous
Next ❯

Citations

Oct 30, 2019·PloS One·Lucas Silva AbreuJosean Fechine Tavares
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zihao ChangLanzhen Zhang
Jun 30, 2019·Journal of Ethnopharmacology·Paulo Vitor Moreira RomãoArquimedes Gasparotto Junior

❮ Previous
Next ❯

Methods Mentioned

BETA
column chromatography

Software Mentioned

Peakview

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Yao xue xue bao = Acta pharmaceutica Sinica
Qiao-Li ZhaoYu-Ying Zhao
Yao xue xue bao = Acta pharmaceutica Sinica
Yong-hong LiangDe-An Guo
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Kun LiuQian Wang
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Yi-xi YangHai-sheng Chen
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Yao-Lan LiWen-Cai Ye
© 2022 Meta ULC. All rights reserved