PMID: 58959Jul 1, 1976

Isolation and immunologic characterization of a human. B-lymphocyte-specific, cell surface antigen

The Journal of Experimental Medicine
R E HumphreysJ L Strominger

Abstract

In addition to HL-A antigens, another cell surface protein complex has been obtained from membranes of the human B-lymphoblast cell line IM-1. This complex which was solubilized with papain, consisted of polypeptides of 23,000 and 30,000 daltons (p23, 30). Rabbit antisera to this material precipitated from [35S]methionine-labeled detergent-solubilized cells, three proteins of 39,000, 34,000, and 29,000 daltons. These antisera were specifically cytotoxic for B lymphocytes of peripheral blood, for B-lymphoblast cell lines, and for EAC rosette receptor-positive surface Ig-negative (Null) lymphocytes. The p23,30 complex was not present on T lymphocytes, EAC rosette receptor-negative Null lymphocytes, or platelets. In addition, the p23,30 complex from several cell lines inhibited alloantisera from multiparous Amish women which had been shown to recognize non-HL-A, B-lymphocyte antigens. Some other properties of the anti-p23,30 sera antisera were described.

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J M McCuneJ L Strominger
Jul 1, 1975·The Journal of Experimental Medicine·D L MannD B Amos
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S F SchlossmanJ L Strominger
Nov 1, 1975·The Journal of Experimental Medicine·S M FuH G Kunkel
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S E CullenS G Nathenson
Mar 15, 1973·Journal of Molecular Biology·L V Crawford, R F Gesteland

Citations

Jan 1, 1982·Immunogenetics·H J DeegR Storb
Jan 1, 1982·Springer Seminars in Immunopathology·M C MingariL Moretta
Dec 30, 1983·Journal of Immunological Methods·A FerreiraP Gonzalez-Porqué
May 1, 1981·Molecular Immunology·S CarrelR S Accolla
Aug 1, 1981·Human Immunology·J M PesandoS F Schlossman
Aug 1, 1982·Human Immunology·R V RouseI L Weissman
Feb 1, 1986·Human Immunology·P J Knudsen, J L Strominger
Mar 1, 1989·Human Immunology·Q V NguyenR E Humphreys
Jun 1, 1978·Clinics in Haematology·T Mohanakumar, R B Raney
Jan 20, 1977·Nature·L KlareskogP A Peterson
Mar 16, 1978·Nature·R L IkemanL M Jerry
Oct 26, 1978·Nature·L KlareskogP A Peterson
Apr 24, 1980·The New England Journal of Medicine·A A Bom-van NoorloosC J Melief
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·V LeeL A Greene
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J SilverJ A Frelinger
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M McMillanL Hood
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S M FriedmanL Chess
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R J WinchesterH E Broxmeyer
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P AllisonJ Silver
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J F Kaufman, J L Strominger
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R S AccollaG Corte
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J S Pober, M A Gimbrone
Nov 1, 1977·British Journal of Haematology·G JanossyK Welsh
Feb 1, 1979·British Journal of Haematology·A E Stuart, A E Dewar
Jan 1, 1976·Scandinavian Journal of Immunology·R J WinchesterT Hoffman
Mar 1, 1978·Scandinavian Journal of Immunology·L KlareskogP A Peterson
Jan 1, 1979·Scandinavian Journal of Immunology·E BerntorpO Zettervall
Jan 1, 1979·Scandinavian Journal of Immunology·J K LunneyD H Sachs
Jan 1, 1979·Scandinavian Journal of Immunology·P NiaudetD Horwitz
Feb 1, 1980·The Journal of Clinical Investigation·T MoritoR C Williams
Feb 1, 1983·Journal of the American Academy of Dermatology·J H Keeling, C W Lewis
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman
Jan 1, 1980·Leukemia Research·R C SpiroR E Humphreys
May 1, 1990·Clinical Immunology and Immunopathology·T HishikawaT Shirai
Jan 1, 1982·Immunological Reviews·D A ShackelfordJ L Strominger
Mar 23, 2006·Annual Review of Immunology·J L Strominger
Apr 1, 1981·Immunology Today·E L Reinherz, S F Schlossman
Jan 1, 1988·Leukemia Research·X R Yao, R E Humphreys
Jan 1, 1980·Leukemia Research·H P KoefflerD W Golde
Apr 20, 2018·The FEBS Journal·Peter Parham
Sep 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K L KaplanV P Butler
Dec 8, 1977·Nature·R S BaschM F Greaves
Apr 20, 2001·International Immunology·J Schwab, H Illges
Apr 1, 1981·Journal of Clinical Immunology·L BusincoF Aiuti
Sep 1, 1977·European Journal of Immunology·I S TrowbridgeG Klein
Jan 1, 1979·Acta Medica Scandinavica·I TuressonO Zettervall
Oct 1, 1977·Tissue Antigens·R BillingJ Lesch
Jan 1, 1977·Scandinavian Journal of Immunology·D Albrechtsen
May 1, 1979·European Journal of Immunology·M F GreavesA Hayward
Nov 1, 1976·European Journal of Immunology·I S TrowbridgeC Mazauskas
Nov 1, 1989·American Journal of Hematology·L J ThomasQ V Nguyen
Jan 1, 1977·Scandinavian Journal of Immunology·R D ArbeitH B Dickler
Nov 1, 1990·American Journal of Hematology·C H SorliR E Humphreys
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·M PetzschE Grundmann
Oct 1, 1980·European Journal of Immunology·E L ReinherzS F Schlossman
Jan 1, 1980·American Journal of Hematology·L W DiamondH Rappaport
Dec 1, 1979·Hoppe-Seyler's Zeitschrift für physiologische Chemie·L G GürtlerH Cleve

Related Concepts

Antigen-Antibody Reactions
Antigenic Specificity
B-Lymphocytes
Beta-2 Microglobulin
Blood Platelets
Microcytotoxicity Test
HLA Antigens
Alloantigens
Lymphocyte Culture Test, Mixed
Protein Conformation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

© 2021 Meta ULC. All rights reserved