Aug 1, 1993

Isolation and investigation of Staphylococcus aureus strains resistant to the membrane active antibiotic, gramicidin S

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
V G BulgakovaA N Polin

Abstract

Strains of Staphylococcus aureus 209P growing in the presence of 20 micrograms/ml of gramicidin S were isolated after the successive subculture on a liquid medium with increasing concentrations of the antibiotic. The resistance was stable and preserved after the subculture on media not containing the antibiotic. The development of the resistance to gramicidin S did not lower the cell sensitivity to a large number of antibiotics known as inhibitors of the cell wall synthesis, protein synthesis and RNA-polymerase reaction. There was observed the development of moderate resistance to actinomycin D but not to other antibiotics interacting with DNA. The gramicidin resistant strains were also resistant to tyrocidine, a membrane active polypeptide. By the amount of the bound gramicidin S the cells of the sensitive and resistant strains did not practically differ.

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Mentioned in this Paper

Antibiotic Resistance, Microbial
Polymerase
Microbial Subculture
Antibiotic throat preparations
Gramicidin S
Antifungal Antibiotics, Topical
Rapicidin
Protein Biosynthesis
Gramicidin NF
Antibiotics, Gynecological

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