PMID: 3755817Aug 11, 1986Paper

Isolation and nucleotide sequence of a cDNA clone encoding rat mitochondrial malate dehydrogenase

Nucleic Acids Research
P M GrantA W Strauss

Abstract

We have determined the complete sequence of the rat mitochondrial malate dehydrogenase (mMDH) precursor derived from nucleotide sequence of the cDNA. A single synthetic oligodeoxynucleotide probe was used to screen a rat atrial cDNA library constructed in lambda gt10. A 1.2 kb full-length cDNA clone provided the first complete amino acid sequence of pre-mMDH. The 1014 nucleotide-long open reading frame encodes the 314 residue long mature mMDH protein and a 24 amino acid NH2-terminal extension which directs mitochondrial import and is cleaved from the precursor after import to generate mature mMDH. The amino acid composition of the transit peptide is polar and basic. The pre-mMDH transit peptide shows marked homology with those of two other enzymes targeted to the rat mitochondrial matrix.

References

Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A W StraussA W Alberts
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T JohY Morino
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M I LomaxL I Grossman
Jun 1, 1981·European Journal of Biochemistry·R ZimmermannW Neupert
Oct 12, 1981·FEBS Letters·L E AzizK B Freeman
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 27, 1984·Biochimica Et Biophysica Acta·R HayS Gasser
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K MorohashiT Omura
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J J BirktoftL J Banaszak
Jan 10, 1981·Nucleic Acids Research·R GranthamR Mercier

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Citations

May 1, 1996·Journal of Cellular Physiology·S MazurekE Eigenbrodt
Jun 1, 1992·Brain Research. Molecular Brain Research·H M LachmanF A Henn
Jan 1, 1992·Brain Research. Molecular Brain Research·E D WeinerH M Lachman
Oct 22, 2003·Molecular Genetics and Metabolism·Victoria Del GaizoR Mark Payne
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P HendrickL E Rosenberg
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J AytéF G Hegardt
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·K S Quandt, D E Hultquist
Apr 29, 2011·Molecular Biology of the Cell·F-Nora VögtleChris Meisinger
Apr 1, 1995·Plant Physiology·O PoeydomengeJ Grima-Pettenati
Apr 1, 1989·European Journal of Biochemistry·G von HeijneR G Herrmann
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·J DaiA Churg
Mar 1, 2000·American Journal of Respiratory Cell and Molecular Biology·C ChassagneE Teiger
May 30, 2002·American Journal of Respiratory Cell and Molecular Biology·Jin DaiAndrew Churg
Oct 1, 1992·The Journal of Clinical Investigation·G J SchwartzJ M Sands
Dec 13, 2000·Journal of Molecular and Cellular Cardiology·B E RupertT D Scholz
Jul 22, 2010·The European Journal of Neuroscience·Manisha NautiyalSusan M Hutson
Feb 14, 1992·Archives of Biochemistry and Biophysics·J S SteffanL McAlister-Henn
Jun 1, 1991·Archives of Biochemistry and Biophysics·J S Steffan, L McAlister-Henn
Nov 26, 1986·Biochemical and Biophysical Research Communications·S M Chien, K B Freeman
Jun 6, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Victoria Del Gaizo, R Mark Payne
Mar 5, 1988·Journal of Molecular Biology·H TakeshimaY Matsukado
Aug 13, 2004·The European Journal of Neuroscience·Philippe GarnierAlain Beley
Jun 27, 1998·The Journal of Biological Chemistry·K S Crowley, R M Payne
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R H LaneS U Devaskar
Mar 5, 1998·The American Journal of Physiology·S TsuruokaG J Schwartz
Feb 1, 2000·Journal of Molecular and Cellular Cardiology·T D ScholzB C Schutte
Dec 14, 1993·Biochimica Et Biophysica Acta·B E HainlineA W Strauss
Jan 18, 1989·Biochimica Et Biophysica Acta·F U HartlW Neupert
May 1, 1988·Trends in Biochemical Sciences·L McAlister-Henn
Nov 1, 1987·Journal of Bacteriology·L McAlister-Henn, L M Thompson

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