PMID: 6968073Jun 1, 1980Paper

Isolation and partial chemical characterization of the IgG Fc receptor of human T lymphocytes and production of an antiserum

Proceedings of the National Academy of Sciences of the United States of America
C Cunningham-RundlesR A Good

Abstract

We report here the isolation of an IgG Fc receptor from normal human T lymphocytes. The purified receptor has a nonreduced and a reduced component of molecular weights 120,000 and 60,000, respectively, and it was functionally active in the in vitro blocking of rosette formation between T lymphocytes and IgG-coated ox erythrocytes. An antiserum raised to the Fc receptor and an isolated F(ab')2 fragment of this antiserum, also blocked rosette formation between T cells and IgG-coated ox erythrocytes. In contrast, rosette formation between T lymphocytes and IgM-coated ox or sheep erythrocytes was not blocked by the F(ab')2 fragment, demonstrating the marked specificity of this antiserum for the IgG Fc receptor. In addition, this antiserum did not block the Fc receptors of non-T cells, indicating that the T-cell IgG Fc receptor has unique antigenic determinants not shared with B cells.

References

Sep 18, 1975·Nature·L RaskP A Peterson
Oct 1, 1977·European Journal of Immunology·A BourgoisR M Parkhouse
Sep 15, 1978·Cellular Immunology·M A Kall, H S Koren
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S GuptaR A Good
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C D PlatsoucasS Gupta
Jun 1, 1978·Immunochemistry·C Cunningham-RundlesR A Good
Jul 1, 1972·The Journal of Experimental Medicine·H B Dickler, H G Kunkel
Jul 1, 1974·Analytical Biochemistry·S C MarchP Cuatrecasas
Feb 21, 1967·Biochimica Et Biophysica Acta·K R Woods, K T Wang
May 1, 1961·Archives of Biochemistry and Biophysics·A NISONOFF, M M RIVERS

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Citations

Apr 22, 1985·Journal of Immunological Methods·R Kurlander, J Niedel
Dec 1, 1981·The Journal of Clinical Investigation·A KulczyckiL Cohen
Jan 1, 1981·Journal of Clinical Immunology·S Cunningham-RundlesR A Good
Jul 16, 2008·Journal of Leukocyte Biology·Maurizio BrigottiPier Luigi Tazzari
Sep 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maurizio BrigottiMarco A Cassatella
Dec 24, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Domenica CarnicelliMaurizio Brigotti
Oct 30, 2007·Journal of Medical Microbiology·Thomas P GrienerGlen D Armstrong
Sep 27, 1980·British Medical Journal·K Sikora
Jul 1, 1986·International Reviews of Immunology·C Neauport-SautesW H Fridman
Jan 1, 1981·Immunological Reviews·W H FridmanR H Gisler

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