PMID: 7513243Jan 1, 1993Paper

Isolation and sequence analysis of peptides from the venom of Protonectarina sylveirae (Hymenoptera-Vespidae)

Natural Toxins
K DohtsuT Nakajima

Abstract

Three new venom peptides were isolated from the Brazilian wasp; Protonectarina sylveirae and their complete amino acid sequences were determined by Edman degradation as well as by FAB-mass spectrometry. One (P-8) of them was a new analog of mastoparan family; therefore, we named it Protonectarina mastoparan. Another peptide (P-10) had an amino acid sequence homology with Ves-CP-T, a chemotactic peptide of wasp venom, and bombolitin-V, the venom peptide from bumblebee. The third peptide (P-6) was structurally unique, possessing an intramolecular disulfide bond. Not only Protonectarina mastoparan (P-8) but also P-6 and P-10 caused histamine release from rat peritoneal mast cells as potently as mastoparan (EC50s were about 1 x 10(-6) M for P-6 and 2 x 10(-6) M for P-10). In addition, P-10 in a concentration higher than 1 x 10(-5) M induced hemolysis though whose hemolytic activity was about a half potency of that of mastoparan. However, P-6 did not cause hemolysis up to the concentration of 10 microM. We have named them sylverin for the peptide P-6 and protonectin for the peptide P-10.

Citations

Jun 23, 2011·Journal of Proteomics·Nicoli Barão Baptista-SaidembergMario Sergio Palma
Oct 18, 2012·Journal of Insect Physiology·Sébastien J M Moreau
Mar 5, 2016·Toxins·Helen Andrade ArcuriMario Sergio Palma
Jul 1, 2004·Toxicon : Official Journal of the International Society on Toxinology·Maria Anita MendesMario Sergio Palma
Sep 11, 2014·Chembiochem : a European Journal of Chemical Biology·Yen-Chu LinGisbert Schneider
Dec 5, 2006·Biological & Pharmaceutical Bulletin·Kazuya MurataTerumi Nakajima
Sep 10, 2015·Rapid Communications in Mass Spectrometry : RCM·Axel TouchardPierre Escoubas
May 2, 2018·Toxicon : Official Journal of the International Society on Toxinology·José Roberto Aparecido Dos Santos-PintoMario Sergio Palma
Jun 6, 2021·Journal of Colloid and Interface Science·Danubia Batista MartinsMarcia Perez Dos Santos Cabrera
Dec 8, 2004·Toxicon : Official Journal of the International Society on Toxinology·Maria Anita MendesMario Sergio Palma
Jul 6, 2010·Toxicon : Official Journal of the International Society on Toxinology·Nicoli B Baptista-SaidembergMario S Palma
Oct 28, 2009·Toxicon : Official Journal of the International Society on Toxinology·Ji Hyeong Baek, Si Hyeock Lee
Jan 26, 2010·Toxicon : Official Journal of the International Society on Toxinology·Ji Hyeong Baek, Si Hyeock Lee

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