Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis

Journal of Natural Products
F D HorgenR A Edrada

Abstract

A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
May 1, 1982·Planta medica·B N MeyerJ L McLaughlin

❮ Previous
Next ❯

Citations

May 29, 2012·Phytochemistry·Nabil Ali Al-MekhlafiNordin H Lajis
Dec 28, 2004·Journal of Ethnopharmacology·Hideka Kobayashi, Elvira de Mejía
Apr 9, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F D HorgenN R Farnsworth
Oct 19, 2011·Toxicology Mechanisms and Methods·Elvira González de Mejía, Marco Vinicio Ramírez-Mares
Jan 19, 2019·Chemistry & Biodiversity·Thalía I Ramírez-ReyesJosé A Guerrero-Analco
Aug 23, 2019·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Md ShahinozzamanShinkichi Tawata
Jul 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pei Lou WongFaridah Abas
Dec 10, 2020·Phytochemical Analysis : PCA·Pei Lou WongFaridah Abas
Mar 28, 2006·Journal of Natural Products·Gordon M CraggStringner S Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.