Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

Journal of Natural Products
George R PettitJames A Duke

Abstract

A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.

References

Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Oct 17, 2015·Journal of the American Chemical Society·Bichu Cheng, Dirk Trauner
Jan 15, 2013·Journal of Ethnopharmacology·Mariana M G PinheiroPatrícia D Fernandes
Mar 19, 2013·Journal of Ethnopharmacology·Ulrike B BreitbachMaria G L Brandão
Feb 12, 2005·Organic Letters·Jorge García-FortanetJef K De Brabander
Mar 27, 2021·Journal of Ethnopharmacology·Éverton Leandro de França FerreiraMariana Helena Chaves
Jan 8, 2008·Journal of Natural Products·George R PettitJean-Charles Chapuis

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