Isolation by Miniaturized Culture Chip of an Antarctic bacterium Aequorivita sp. with antimicrobial and anthelmintic activity

Biotechnology Reports
Fortunato Palma EspositoDonatella de Pascale

Abstract

Microbes are prolific sources of bioactive molecules; however, the cultivability issue has severely hampered access to microbial diversity. Novel secondary metabolites from as-yet-unknown or atypical microorganisms from extreme environments have realistic potential to lead to new drugs with benefits for human health. Here, we used a novel approach that mimics the natural environment by using a Miniaturized Culture Chip allowing the isolation of several bacterial strains from Antarctic shallow water sediments under near natural conditions. A Gram-negative Antarctic bacterium belonging to the genus Aequorivita was subjected to further analyses. The Aequorivita sp. genome was sequenced and a bioinformatic approach was applied to identify biosynthetic gene clusters. The extract of the Aequorivita sp. showed antimicrobial and anthelmintic activity towards Multidrug resistant bacteria and the nematode Caenorhabditis elegans. This is the first multi-approach study exploring the genomics and biotechnological potential of the genus Aequorivita that is a promising candidate for pharmaceutical applications.

Citations

Feb 23, 2020·Applied Microbiology and Biotechnology·Angelina Lo GiudiceCarmen Rizzo
Jul 7, 2020·Journal of Applied Microbiology·Fluvio ModolonRaquel S Peixoto

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Datasets Mentioned

BETA
MH012204
CIP
111184

Methods Mentioned

BETA
Chip
chips
dissection
PCR
ELISA
Nuclear Magnetic

Software Mentioned

antibiotics and
Secondary Metabolite Analysis Shell (
MEGA7
MarPipe
- SMASH )
Musket
FLASH
anti
AlienTrimme
khmer

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.