PMID: 2507645Nov 1, 1989Paper

Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene

The Journal of Investigative Dermatology
B S KwonR Halaban

Abstract

Using a human tyrosinase cDNA probe, we have isolated mouse tyrosinase genomic clones and used them to map the mouse tyrosinase locus and to analyze the promoter sequence of the tyrosinase gene. Southern blot analyses of DNA from somatic cell hybrids, interspecies backcross mice, and albino deletion mice have revealed that the locus for mouse tyrosinase resides at or near the albino locus on mouse chromosome 7. There were three TATA-elements, but only one CAT-element, and the CAT-element appeared to be paired with the third TATA-element, located at the position farthest upstream. Mouse tyrosinase mRNA is approximately 2.4 Kb in size. The amount of tyrosinase mRNA reflects the levels of tyrosinase activity in normal melanocytes and Cloudman S-91 melanoma cell line.

Citations

Nov 3, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Friedrich BeermannM Lynn Lamoreux
Jan 1, 1992·Pigment Cell Research·R Halaban, G Moellmann
Sep 1, 1996·Journal of Cellular Physiology·H MahalingamR M Niles
Mar 9, 2019·Journal of Natural Medicines·Weicheng WangHisashi Matsuda
Jan 11, 1992·Pigment Cell Research·W C Quevedo, T J Holstein
Aug 1, 1993·Pigment Cell Research·K UrabeV J Hearing
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·R HalabanD N Hebert
Sep 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I J Jackson
Mar 17, 2006·Cancer Research·Ivo J HuijbersBenoît J Van den Eynde
Jun 20, 1998·Biochemical Pharmacology·D WattersP Parsons
Aug 23, 2002·The Journal of Investigative Dermatology·Ruth HalabanDaniel N Hebert
Aug 1, 1993·The Journal of Investigative Dermatology·S J OrlowB K Zhou
Jul 15, 1991·Biochemical and Biophysical Research Communications·C D ChintamaneniB S Kwon
Apr 13, 2010·Trends in Genetics : TIG·Joanna K HubbardRebecca J Safran

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