Isolation, identification, and quantification of triterpene saponins in the fresh fruits of Panax notoginseng.

Natural Product Research
Zheng-Yi QuYing-Ping Wang

Abstract

This study is to develop a method for isolation, identification, and quantitative determination of dammarane-type triterpene saponins in the Panax notoginseng fruits (PNF). The saponins were isolated by a serious of chromatographic methods, and their structures were elucidated on the basis of spectroscopic evidence and comparison with those of literature reports. Quantitative assay was performed on an ultra-performance liquid chromatography-UV (UPLC-UV) method. As a result, 22 saponins were isolated from the extract of PNF, among them, compound 1 was a new saponin, named as malonylgypenoside IX, compounds 3-10, and 14-18 were isolated from the PNF for the first time. As to quantitative analysis, the calibration curves showed good linearity (r > 0.998) within the concentration range, and the method validation provided good reproducibility and sensitivity for the quantification of eight major saponins with precision and accuracy of less than 3.0%.

References

Oct 16, 2007·Journal of Agricultural and Food Chemistry·Ying HanYuqing Zhao
May 31, 2011·Journal of Asian Natural Products Research·Ying PeiYing-Jun Zhang
May 29, 2012·Fitoterapia·Ke-Ke LiXiao-Jie Gong
Jan 13, 2015·Journal of Pharmaceutical and Biomedical Analysis·Jin-Yi WanLian-Wen Qi
Aug 2, 2017·Natural Product Research·Cheng-Zhen GuYing-Jun Zhang
Feb 26, 2019·Journal of Ethnopharmacology·Congcong XuNing Li
Feb 7, 2021·Fitoterapia·Zheng-Yi QuYing-Ping Wang

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