PMID: 2105461Jan 1, 1990Paper

Isolation of a Bacillus subtilis mutant defective in constitutive O6-alkylguanine-DNA alkyltransferase

Mutation Research
F Morohoshi, N Munakata

Abstract

A mutant of Bacillus subtilis defective in the constitutive activity of O6-alkylguanine-DNA alkyltransferase was isolated from a strain (ada-1) deficient in the adaptive response to DNA alkylation. Cells carrying the mutation dat-1 which was responsible for the defect in constitutive activity exhibited hypersensitivity for lethality and mutagenesis when challenged with methyl-nitroso compounds. The constitutive activity is independent of the adaptive response, and seems to function as a basal defense against environmental alkylating agents.

References

May 19, 1977·Nature·L Samson, J Cairns
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G W RebeckL Samson
Jan 1, 1982·Annual Review of Biochemistry·T Lindahl
Jan 5, 1982·Journal of Molecular Biology·B Sedgwick, T Lindahl

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Citations

Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Justin S LenhartLyle A Simmons

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